 | | Vol. 13.15 – 21 April, 2022 |
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| Researchers showed that while Loxl2 ablation had little effect on primary tumour development and growth, its loss significantly decreased metastasis and increased overall survival. They attributed this effect to non-cell autonomous factors, primarily ECM remodeling.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists systematically studied the impact of matrix stiffness and hemodynamic pressure on vascular smooth muscle cells (VSMCs). They found that pressure and stiffness individually affected the VSMC phenotype.
[Science Advances] |
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| The authors found a 3D matrix-specific mechanoresponsive mechanism for neural stem cell differentiation. Egr1 knockdown enhanced neurogenesis in stiff ECMs by driving β-catenin nuclear localization and activity in 3D, but not in 2D.
[Science Advances] |
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| The regulatory effects of Gremlin-1 (Grem1) on apoptosis were examined using siRNAs, flow cytometry, immunofluorescence, and western blotting.
[Experimental & Molecular Medicine] |
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| Investigators demonstrated that extracellular ATP treatment could upregulate the expression of connective tissue growth factors in both triple-negative breast cancer (TNBC) cells and endothelial cells.
[Cancer Science] |
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| Scientists investigated the biology of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulation and systemic effects of CFTR restoration by examining changes in circulating measurements of inflammation and growth and novel proteins with ivacaftor treatment.
[Journal of Cystic Fibrosis] |
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| Researchers demonstrated that sirtuin 1 (SIRT1) repressed the ubiquitination of epidermal growth factor receptor (EGFR) by down-regulating phosphatase and tensin homolog (PTEN), inhibited ECM degradation, and activated chondrocyte autophagy, thereby performing an osteoarthritis-alleviating role.
[Cell Death Discovery] |
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| The authors reported that the voltage-gated calcium channel α2δ1 subunit-positive tumor-initiating cells of hepatocellular carcinoma specifically secreted LOX, which led to the crosslinking of collagen, forming a stiff ECM that was sufficient to drive the formation of tumor-initiating cells with a stiff mechanical trait.
[Carcinogenesis] |
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| Investigators found that milk fat globule-EGF factor-8 (MFG-E8)’s expression was reduced in degraded nucleus pulposus tissues of humans and rats as well as hydrogen peroxide-treated nucleus pulposus cells.
[Cell Death Discovery] |
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| Researchers investigated the biochemical effect of the cosmetic potential of selected Apiaceous essential oils, traditionally used for skincare, by evaluating their anti-wrinkle activity.
[Scientific Reports] |
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| IL-17 was utilized to induce human keloid fibroblasts and normal dermal fibroblasts. With the application of RT-qPCR and Western blot, TRAF3IP2 expression was detected.
[Journal of Cosmetic Dermatology] |
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| The authors provide an overview of the role of matrix viscoelasticity in directing cell behavior towards regenerative outcomes, highlight recent strategies utilizing viscoelastic hydrogels for regenerative therapies.
[Tissue Engineering Part C-Methods] |
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| Investigators discuss how the development of therapeutics to combat cardiac diseases, specifically fibrosis, relies on a deeper understanding of how the cardiac ECM is intertwined with signaling processes that underlie cellular activation and behavior.
[Nature Cardiovascular Research] |
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| A pair of Rutgers researchers will collaborate with Atelier Meats, a biotechnology company, to develop and produce lab-grown, structured meats. Mao and Freeman will assist in the development of Atelier’s proprietary technology to develop a process to produce lab-grown/cultivated meats.
[Rutgers University] |
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| A University of Iowa professor, Dr. James Ankrum, will travel to Ireland for a collaborative effort aimed at advancing research in the field of regenerative medicine.
[The Daily Iowan] |
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| June 12 – 16, 2022
Keystone, Colorado, United States |
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| | University of Manchester – Manchester, England, United Kingdom |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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