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| The authors designed a mesoporous silica nanospheres-based vehicle that suggested a robust space-time conversion strategy to achieve programmed multi-drugs delivery and represented a new avenue to the treatment of pancreatic carcinoma by overcoming ECM and drug reflux barriers.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributed to osteoarthritis progression.
[Nature Communications] |
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| Investigators found that the stimulation of an electrode locally changed the ratio of the two major cell types comprising Bacillus subtilis biofilms, namely motile and ECM-producing cells.
[Cell Systems] |
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| Inhibition of TGF-β signaling with SB431542-containing nanoparticles significantly reduced p-Smad2–positive cells in the arteriovenous fistulae (AVF) wall during the early maturation phase and was associated with decreased AVF wall thickness.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| Methyl-CpG binding domain protein 3 (MBD3) inhibited the tissue factor pathway inhibitor 2 (TFPI2) transcription via the nucleosome remodeling and deacetylase complex-mediated deacetylation, thus reactivating the activity of matrix metalloproteinases and PI3K/AKT signaling pathway.
[British Journal of Cancer] |
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| Researchers revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARα.
[Molecular Cancer Research] |
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| Investigators explored the effect of FOXO4-D-Retro-Inverso (FOXO4-DRI) on bleomycin (BLM)-induced pulmonary fibrosis mouse model.
[Journal of Cellular and Molecular Medicine] |
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| Scientists found that a m6A-related lncRNA LINC00680 upregulated in the osteoarthritis tissue and IL-1β-induced isolated primary chondrocytes.
[Cell Death Discovery] |
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| The authors demonstrated the derivation of a practical and durable hydrogel from decellularized human pancreas that supported human islet survival and function.
[Scientific Reports] |
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| Researchers provide a comprehensive atlas of the expression patterns of four individual chondroitin sulphate proteoglycans in three models of inherited retinal degeneration and wildtype mice.
[Scientific Reports] |
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| The authors incorporated fingolimod in polylactic-co-glycolic acid and then fabricated an electrospun scaffold composed of polyurethane, polycaprolactone, and gelatin polymers containing different amount of encapsulated fingolimod.
[Polymers For Advanced Technologies] |
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| Scientists indicated the potential biomarkers or therapeutic targets for idiopathic epiretinal membrane (iERM) and provided key kinases that may have been involved in iERM.
[Proteomics Clinical Applications] |
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| Investigators discuss the current clinical landscape of immune-checkpoint inhibitors activity in the CNS and CNS immunobiology and focus on the role of glial cells in the CNS immune response to brain metastasis.
[Cancer Discovery] |
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| The authors summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients.
[npj Precision Oncology] |
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| Axogen, Inc. announced topline results from its RECON Clinical Study comparing Avance Nerve Graft to conduits in digital nerve injuries.
[Axogen, Inc.] |
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| Agastiya Biotech and Vopec Pharmaceuticals announce that the US FDA has granted Orphan Drug Designations for Pancreatic Cancer and AML for its novel small molecule, AB001.
[Agastiya Biotech (Cision US, Inc.)] |
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| August 7 – 12, 2022
Andover, New Hampshire, United States |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | New York University College of Dentistry – New York, New York, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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