A Space-Time Conversion Vehicle for Programmed Multi-Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers

The authors designed a mesoporous silica nanospheres with a sandwiched polyethyleneimine-based vehicle that suggested a robust space–time conversion strategy to achieve programmed multi-drugs delivery and represented a new avenue to the treatment of pancreatic carcinoma by overcoming ECM and drug reflux barriers.