Extracellular Matrix News Volume 13.21 | Jun 2 2022

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    2022-06-02 | ECM 13.21


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.21 – 2 June, 2022
    TOP STORY

    Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway

    Scientists found that by tuning the microneedle (MN) size and density only, the biocompatible MNs significantly decreased the scar elevation index in the rabbit ear hypertrophic scar model and increased ultimate tensile strength close to regular skin.
    [ACS Nano]

    Full ArticleGraphical Abstract
    ON987CXN-jun-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Activation of Nkx2.5 Transcriptional Program Is Required for Adult Myocardial Repair

    The authors showed that cardiac-specific RNA-sequencing studies revealed a disrupted embryonic transcriptional profile in the adult Nkx2.5 loss-of-function myocardium.
    [Nature Communications]

    Full Article

    Interaction Between Mesenchymal Stem Cells and Myoblasts in the Context of Facioscapulohumeral Muscular Dystrophy Contributes to the Disease Phenotype

    Researchers used cell motility assays and co-culture of mesenchymal stem cells with myoblasts to study their mutual effects on cell migration, differentiation, proliferation, and extracellular matrix formation.
    [Journal of Cellular Physiology]

    Full Article

    TGF-β Promotes Pericyte-Myofibroblast Transition in Subretinal Fibrosis through the Smad2/3 and Akt/mTOR Pathways

    Investigators explored the role and potential mechanisms by which pericyte-myofibroblast transition contributed to subretinal fibrosis.
    [Experimental & Molecular Medicine]

    Full Article

    A Novel Thermosensitive Growth-Promoting Collagen Fibers Composite Hemostatic Gel

    Upon adjusting the ratios of different materials, COF-3, showing the most comprehensive performance, best in vitro hemostatic effects, good gelation speed, and good cell compatibility, was selected.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    Tissue-Level Regeneration and Remodeling Dynamics are Driven by Mechanical Stimuli in the Microenvironment in a Post-Bridging Loaded Femur Defect Healing Model in Mice

    The authors combined computational approaches in the form of finite element analysis and experimental approaches by using a loaded femoral defect model in mice to investigate the role of mechanical stimulation in the microenvironment of bone.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    The Effects of Rotating Magnetic Field and Antiseptic on In Vitro Pathogenic Biofilm and Its Milieu

    Scientists suggested that the combination of rotating magnetic field and octenidine dihydrochloride-based antiseptic could be particularly promising in eradicating biofilms located in areas such as wound pockets, where physical obstacles limit antiseptic activity.
    [Scientific Reports]

    Full Article

    MMP2 Promotes Osteoblast Differentiation and Calcification of Muscle-Derived Mesenchymal Stem Cells by Interaction with miR-29b-3p

    Researchers found that matrix metalloproteinase 2 (MMP2) could facilitate the osteoblast differentiation and calcification of muscle-derived MSCs by up-regulating the expression of some typical osteogenic differentiation phenotype markers, such as runt-related transcription factor 2 and osteocalcin.
    [Tissue and Cell]

    Abstract
    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Carcinoma Associated Mesenchymal Stem/Stromal Cells – Architects of the Pro-Tumorigenic Tumor Microenvironment

    Scientists review the impact of carcinoma-associated (CA)-MSCs on cancer progression and metastasis and the ongoing work on CA-MSC identification, nomenclature and mechanism of action.
    [Stem Cells]

    Abstract
    Graphical Abstract

    Extracellular Matrix Dynamics: Tracking in Biological Systems and Their Implications

    Investigators outline the mechanisms mediating ECM-cell interactions and highlights how changes in the ECM modulate tissue development and disease progression, using the lung as the primary model organ.
    [Journal of Biological Engineering]

    Full Article
    INDUSTRY AND POLICY NEWS

    Rensselaer Polytechnic Institute and Icahn School of Medicine at Mount Sinai Announce Joint Center for Engineering and Precision Medicine

    Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai recently announced the creation of the Center for Engineering and Precision Medicine, one of the first centers in the nation to bridge engineering and engineering science with medicine.
    [Rensselaer Polytechnic Institute]

    Press Release

    Bioengineers Work on New Technology to Look Deep Inside Living Tissue and Tumors

    Bioengineering Professor Changqing Li began building a high-resolution CT imaging scanner that will allow scientists to study and understand how oxygen plays a role in cancer therapy and stem cells growing in deep tissue such as bone marrow.
    [University of California]

    Press Release
    FEATURED EVENT

    Neurobiology of Brain Disorders

    August 7 – 12, 2022
    Castelldefels, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Specialist – Stem Cells and Regenerative Medicine

    Stem Cell Network – Ottawa, Ontario, Canada

    Researchers – Biology and Medicine

    China Medical University – Shenyang, China

    Postdoctoral Fellow – Female Reproductive Biology

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    PhD Studentship – Extracellular Matrix Adhesion and Cell Cycle Progression

    University of Plymouth – Plymouth, England, United Kingdom

    > See All Jobs

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