Extracellular Matrix News Volume 13.24 | Jun 23 2022

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    2022-06-23 | ECM 13.24


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.24 – 23 June, 2022
    TOP STORY

    Stoichiometric Post Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds

    To create plain hydrogel microparticles (HMPs) that could later be converted to contain different types of bioactivities, scientists utilized the inverse electron-demand Deiels-Alder reaction between tetrazine and norbornene, which allowed them to post modify plain HMPs stoichiometrically.
    [Advanced Materials]

    Abstract
    View tips on how to organize your lab bench space.
    PUBLICATIONSRanked by the impact factor of the journal

    3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds

    Researchers used porous 3D scaffolds, designed with two different porosities along with 2D tissue culture polystyrene plates were used with a model breast cancer human cell line.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes

    Integration of the core matrisome and curated FANTOM5 SSTAR data creates a unique tool that provides insight into the promoter-level expression of ECM-encoding genes in a tissue- and cell-specific manner.
    [Matrix Biology]

    Abstract

    A Sonication-Induced Silk-Collagen Hydrogel for Functional Cartilage Regeneration

    Scientists developed a sonication-induced silk-collagen composite hydrogel and investigated its physicochemical and biological properties compared with a collagen hydrogel and a non-sonicated silk-collagen composite hydrogel.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    miR-218 Affects the ECM Composition and Cell Biomechanical Properties of Glioblastoma Cells

    Investigators reported that ECM composition was partially regulated at the post-transcriptional level by miRNA.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Adipose Cells and Tissues Soften with Lipid Accumulation While in Diabetes Adipose Tissue Stiffens

    Scientists quantified by optical diffraction tomography that differentiating preadipocytes increased their volumes drastically.
    [Scientific Reports]

    Full Article

    Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling

    The impact of laminin-511 on human induced pluripotent stem cells on α6β1 integrin-Fyn-RhoA-ROCK signaling was discussed and explored along with validation experiments.
    [Stem Cells and Development]

    Abstract

    Efficient Engineering of Human Auricular Cartilage through Mesenchymal Stem Cell Chaperoning

    To significantly decrease the number of chondrocytes required for human elastic cartilage engineering, the authors co-cultured human mesenchymal stem cells with auricular chondrocyte to promote healthy elastic cartilage formation.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    Fibroblast Growth Factor 2 Inhibits Myofibroblastic Activation of Valvular Interstitial Cells

    Investigators isolated valvular interstitial cells from diseased human valves and treated these cells with fibroblast growth factor 2 and TGF-β to elucidate effect of these growth factors on several myofibroblastic outcomes, in particular immunocytochemistry and gene expression.
    [Plos One]

    Full Article

    Arctigenin Inhibits Apoptosis, Extracellular Matrix Degradation, and Inflammation in Human Nucleus Pulposus Cells by Up-Regulating miR-483-3p

    Interleukin (IL)-1β was adopted to induce human nucleus pulposus cells as a cell model for intervertebral disc degeneration.
    [Journal of Clinical Laboratory Analysis]

    Full Article
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Extracellular Microenvironmental Control for Organoid Assembly

    The authors summarize the natural tissue and organ’s unique chemical and mechanical properties, guiding researchers to design an extracellular microenvironment used for organoid engineering
    [Tissue Engineering Part B-Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies Announces Clinical Trial Contract with Second Site for the Company’s Phase II Clinical Trial to Treat Chronic Lumbar Disc Disease (cLDD)

    BioRestorative Therapies, Inc. announced it has reached an agreement with its second clinical site for its Phase II clinical trial targeting chronic lumbar disc disease.
    [BioRestorative Therapies, Inc.]

    Press Release
    FEATURED EVENT

    49th European Muscle Conference

    September 23 – 26, 2022
    Prague, Czech Republic

    > See All Events

    JOB OPPORTUNITIES

    Research Investigator – Drug Discovery

    InCyte – Wilmington, Delaware, United States

    Research Fellow – Biochemistry & Molecular Biology

    Max Planck Institute of Biochemistry – Munich, Germany

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    Postdoctoral Fellow – Tumor Microenvironment

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Researcher – Stem Cells and Regenerative Medicine

    Aarhus University – Aarhus C, Denmark

    > See All Jobs

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