 | | Vol. 13.25 – 30 June, 2022 |
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| The diversity of gene expression and genome accessibility by mouse CD8+ tissue-resident memory T cells from distinct organs that responded to viral infection revealed both shared and tissue-specific transcriptional and epigenetic signatures.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists employed single-cell RNA sequencing to characterize the immune composition of an undifferentiated pleiomorphic sarcoma mouse model, showing that macrophages in the sarcoma mass exhibit distinct activation states.
[Cell Reports] |
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| Four types of stepwise decellularized ECMs were prepared from bone marrow-derived mesenchymal stem cells undergoing osteogenic differentiation for 0, 7, 14, and 21 days after decellularization.
[Journal of Materials Chemistry B] |
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| The authors showed that the direct injection of a hyaluronic acid-based microporous annealed particle hydrogel into the stroke core in mice reduced the percent of highly reactive astrocytes, increased the percent of alternatively activated microglia, decreased cerebral atrophy, and preserves NF200 axonal bundles.
[Advanced Therapeutics] |
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| Researchers evaluated the impact of the inactivation of sodium chloride cotransporter on bone turnover and microarchitecture in Gitelman syndrome patients.
[Osteoporosis International] |
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| ECM biomaterials were prepared as lyophilized particulates from decellularized adventitial specimens of human and porcine aorta.
[Journal of Biomedical Materials Research Part A] |
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| Investigators fabricated a hybrid ECM scaffold from the basic structure of fibroblast-derived cellular ECMs by adding major ECM components of fibronectin and collagen externally.
[Macromolecular Bioscience] |
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| The authors conducted a network-based analysis on 5-hmC levels extracted from circulating free DNAs in gastrointestinal cancers including colon, gastric, and pancreatic cancers, and from healthy donors.
[BMC Genomic Data] |
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| Scientists found that proline, a highly abundant amino acid in collagen proteins, was newly synthesized from glutamine in cancer-associated fibroblasts to make tumor collagen in breast cancer xenografts.
[Nature Metabolism] |
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| Investigators summarize the role of the ECM, particularly the perineuronal nets, in the control of various types of memory and their participation in memory pathology.
[Molecular Psychiatry] |
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| The authors review the metabolic rewiring of cancer cells following radiotherapy and put these observations in the context of the tumor microenvironment (TME) to describe the metabolic hallmarks of radiotherapy in the TME.
[Trends in Cancer] |
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| New biological insights from these tumor microenvironments will enable rational design of strategies that co-target the tumor and stroma, which are expected to improve the outcomes of patients with advanced bladder cancer.
[Nature Reviews Urology] |
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| Vascudyne, Inc. announced that it was awarded a grant from Regenerative Medicine Minnesota for a project titled “Development of a Peripheral Nerve Wrap Using Regenerative Engineering Tissue Tube”.
[NewsDirect.com] |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Max Planck Institute of Biochemistry – Munich, Germany |
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| | Uppsala University – Uppsala, Sweden |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | Aarhus University – Aarhus C, Denmark |
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