Extracellular Matrix News Volume 13.28 | Jul 21 2022

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    2022-07-21 | ECM 13.28


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.28 – 21 July, 2022
    TOP STORY

    Oncogenic Collagen I Homotrimers from Cancer Cells Bind to α3β1 Integrin and Impact Tumor Microbiome and Immunity to Promote Pancreatic Cancer

    The authors identified the functional impact of type I collagen (Col1) homotrimers on tumor microbiome and tumor immunity, implicating Col1 homotrimer-α3β1 integrin signaling axis as a cancer-specific therapeutic target.
    [Cancer Cell]

    Abstract

    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration

    A hyaluronic acid nanocomposite hydrogel was developed based on aldehyde-modified sodium hyaluronate, hydrazide-modified sodium hyaluronate, and aldehyde-modified cellulose nanocrystals, which exhibited improved strength and excellent self-healing ability.
    [ACS Nano]

    Full ArticleGraphical Abstract

    Adherens Junctions Stimulate and Spatially Guide Integrin Activation and Extracellular Matrix Deposition

    Scientists showed that cadherin clustering stimulated and spatially guided integrin activation. Adherens junction-associated integrin activation depended on locally generated tension and did not require ECM ligands.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Chondro-Inductive B-TPUe-Based Functionalized Scaffolds for Application in Cartilage Tissue Engineering

    Researchers functionalized 3D printed 1,4 butanediol thermoplastic polyurethane (b-TPUe) scaffolds and used infrapatellar mesenchymal stem cells as the cellular source.
    [Advanced Healthcare Materials]

    AbstractFull Article

    Regulation of Extracellular Matrix Components by AmrZ Is Mediated by C-Di-GMP in Pseudomonas ogarae F113

    RNA-Seq and qRT-PCR gene expression analyses revealed that AmrZ regulated many genes related to the production of ECM components at the transcriptional level.
    [Scientific Reports]

    Full Article

    Reduced Dynamic Loads Due to Hip Dislocation Induce Acetabular Cartilage Degeneration by IL-6 and MMP3 via the STAT3/Periostin/NF-κB Axis

    Reduced dynamic loads due to hip dislocation induced acetabular cartilage degeneration via IL-6 and MMP3 through STAT3/periostin/NF-κB signaling in rodent disarticulation-developmental dysplasia of the hip models.
    [Scientific Reports]

    Full Article

    Extracellular Matrix Microparticles Improve GelMA Bioink Resolution for 3D Bioprinting at Ambient Temperature

    Adding decellularized ECM microparticles derived from porcine tracheal cartilage to gelatin-methacryloyl created a yield stress fluid capable of forming self-supporting structures.
    [Macromolecular Materials and Engineering]

    AbstractFull Article

    Comparison of Decellularization Protocols for Cultured Cell-Derived Extracellular Matrix—Effects on Decellularization Efficacy, Extracellular Matrix Retention, and Cell Functions

    Scientists compared two physical and five chemical decellularization methods for cultured cell-derived ECM reconstructed by decellularization.
    [Journal of Biomedical Materials Research Part B-Applied Biomaterials]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Bone Remodeling: An Operational Process Ensuring Survival and Bone Mechanical Competence

    The authors summarize the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis.
    [Bone Research]

    Full Article

    Muscle-to-Tumor Crosstalk: The Effect of Exercise-Induced Myokine on Cancer Progression

    Scientists summarize the roles and underlying mechanisms of myokines, such as IL-6, myostatin, IL-15, irisin, fibroblast growth factor 21, and musclin, in cancer cachexia.
    [Biochimica et Biophysica Acta-Reviews On Cancer]

    Abstract

    Engineering Hydrogels for Modulation of Material-Cell Interactions

    The wide variety of sources, crosslinking strategies, and functionalization methods, and mostly the resemblance of hydrogels to the natural ECM, make this 3D hydrated structure an excellent tool for tissue engineering approaches.
    [Macromolecular Bioscience]

    Abstract

    INDUSTRY AND POLICY NEWS

    Acera Surgical, Inc. Announces GPO Agreement with Capstone for its Synthetic Resorbable Hybrid-Scale Fiber Matrix, Restrata®

    Acera Surgical, Inc., a bioscience company developing and commercializing a portfolio of fully synthetic materials for regenerative medical applications, announced it has entered a new phase of growth after signing an agreement with Capstone Health Alliance.
    [Acera Surgical, Inc. (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    The Molecular Metabolism Conference: From Cell Biology to Systems Physiology

    August 7-11, 2022
    Treasure Drive, Nova Scotia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant Professor – Cardiovascular and Regenerative Medicine

    Ohio State University Wexner Medical Center – Columbus, Ohio, United States

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    Postdoctoral Position – Secondary DNA Structures in the ECM of Bacterial Biofilms

    Aarhus University – Aarhus, Denmark

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    > See All Jobs

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