Oncogenic Collagen I Homotrimers from Cancer Cells Bind to α3β1 Integrin and Impact Tumor Microbiome and Immunity to Promote Pancreatic Cancer

The authors identified the functional impact of type I collagen (Col1) homotrimers on tumor microbiome and tumor immunity, implicating Col1 homotrimer-α3β1 integrin signaling axis as a cancer-specific therapeutic target.