 | | Vol. 13.31 – 11 August, 2022 |
| |
|
|
| The authors performed a pan-cancer single-cell RNA-sequencing analysis across 15 cancer types and identified a catalog of gene modules whose expression defined recurrent cancer cell states.
[Nature Genetics] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators found that terminally exhausted T cells had unexpected chromatin features that limited their transcriptional potential.
[Science Immunology] |
|
|
|
| Using temporal proteomic profiling of decellularized tumours, researchers interrogated the evolving matrisome during breast cancer progression.
[Nature Communications] |
|
|
|
| Investigators reported the design and development of highly stretchable, compliant, and enzymatic-resistant transiently cross-linked decellularized ECM.
[ACS Applied Materials & interfaces] |
|
|
|
| Scientists developed a novel ECM-mimicking scaffold by coaxial electrospinning to be endowed with multibiological functions.
[ACS Applied Materials & interfaces] |
|
|
|
| While the relationship between mutations in genes such as the SNCA and LRRK2 and a reduction in synaptic transmission has been investigated before, the authors showed evidence that the pathogenesis of the synapses in neurons was a general phenotype in Parkinson’s disease.
[npj Parkinson’s Disease] |
|
|
|
| Knockdown of circNFKB1 inhibited ECM catabolism and rescued IL-1β impaired ECM anabolism whereas ectopic expression of circNFKB1 significantly promoted chondrocytes degradation in vitro.
[Cell Death & Disease] |
|
|
|
| Researchers focused on a comprehensive analysis of matrix metalloproteinase 1 (MMP1) in hepatocellular carcinoma, specifically the prognosis and tumor-immune microenvironment.
[Scientific Reports] |
|
|
|
| Fibro-adipogenic progenitors’ sensitivity to their ECM substrate was assessed using collagen coated polyacrylamide to control substrate stiffness and collagen hydrogels to engineer concentration, crosslinking, fibril size, and alignment.
[Scientific Reports] |
|
|
|
|
| The effect of matrix stiffness on cancer cells has been described in many studies, whereas its effect on cancer stromal cell fate has rarely been summarized. The authors discuss the relevant content and drug treatment studies targeting matrix stiffness.
[Acta Biomaterialia] |
|
|
|
| Scientists summarize the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in osteoarthritis (OA), suggesting new realms to improve OA management.
[International Journal of Oral Science] |
|
|
|
|
| The WITec Paper Awards 2022 have been given to scientists from the US, Germany, and China, recognizing their work in cement chemistry, pharmacy, and methane hydrate chemistry.
[Oxford Instruments] |
|
|
|
|
|
|
|
| | NIH National Cancer Institute – Bethesda, Maryland, United States |
|
|
|
| | Yale University – New Haven, Connecticut, United States |
|
|
|
| | AstraZeneca – Cambridge, England, United Kingdom |
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
