 | | Vol. 13.32 – 18 August, 2022 |
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| Scientists found that fibrillar collagen-related gene expression was associated with favorable patient prognosis in rhabdomyosarcoma.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that the ECM of livers isolated from chemotherapy-treated MMTV-PyMT mice increased the invasion, but not proliferation, of metastatic breast cancer cells. Proteomic analysis of the liver ECM identified Collagen V to be more abundant in paclitaxel-treated livers.
[Matrix Biology] |
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| Investigators developed a cell proliferation receptor-enhanced 3D high-throughput screening model expressing high cell proliferation receptors that was optimized by the selection of alginate as the ECM.
[Analytical Chemistry] |
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| Gene expression and secretome analyses of cancer-associated fibroblasts and normal lung–associated fibroblasts revealed differential abundance of insulin-like growth factors (IGFs) and IGF-binding proteins, which promoted or inhibited, respectively, signaling by the receptor IGF1R and the kinase FAK.
[Science Signaling] |
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| A thorough behavioral characterization of Collagen VI (COL6) null mice unexpectedly revealed that COL6 deficiency led to a significant impairment in sensorimotor gating and memory/attention functions.
[Disease Models & Mechanisms] |
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| Scientists elucidated fenretinide’s effects on additional invasion-relevant mechanisms including matrix metalloproteinase activation and function, cell-ECM attachments, and interaction with a kinase that was essential for the epithelial-myoepithelial transformation i.e. c-Jun NH2-terminal kinase.
[Carcinogenesis] |
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| Unsorted and non-expanded Merkel cell carcinoma tumor cells were isolated from surgical specimens and suspended in an ECM based hydrogel, along with patient matched blood and lymph node tissue to generate immune enhanced organoids.
[Scientific Reports] |
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| Researchers investigated whether verteporfin was able to inhibit the activation and subsequent differentiation of Dupuytren’s disease nodular fibroblasts into myofibroblasts.
[Scientific Reports] |
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| Using porcine ECM and adhesion molecule array, EGF was shown to induce changes in gene expression of ECM components: MMP1, MMP3, MMP12, LAMA1, SELL and ICAM1, which were abrogated in the presence of Stattic.
[Biology of Reproduction] |
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| To develop reliable scaffold-free periodontal tissue regenerative cell therapy by MSCs/ECM complexes (C-MSCs), scientists investigated the periodontal tissue regenerative capacity of C-MSCs and the behavior of the transplanted cells.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| Investigators found that different concentrations of gelatin methacrylate hydrogel could provide a suitable environment for cell survival. However, hydrogels with different mechanical properties influenced cell adhesion and ECM component type I collagen, type II collagen, and aggrecan expression.
[Tissue Engineering and Regenerative Medicine] |
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| Scientists review the emerging field of mechanoimmunology, focusing on how mechanical cues at the scale of the tissue environment regulate immune cell behaviors to initiate, propagate and resolve the immune response.
[Nature Reviews Immunology] |
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| The mechanism of mechanical regulation of stem cell proliferation and differentiation is summarized based on the pathway of force transduction, including the signal transduction from ECM to nucleus.
[Tissue Engineering Part B-Reviews] |
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| The authors review methods of decellularization, with particular emphasis to cardiac tissue, and how they can affect the biomechanics of the tissue, which in turn determines success of reseeding and in vivo viability.
[American Journal of Physiology-Heart and Circulatory Physiology] |
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| Each year, Baylor College of Medicine faculty are recognized for their outstanding published scientific contributions to clinical and basic science research over the past three years through the Michael E. DeBakey MD Award for Excellence in Research.
[Baylor College of Medicine] |
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| The National Foundation for Cancer Research (NFCR) announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research.
[National Foundation for Cancer Research] |
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| December 10 – 14, 2022
Maui, Hawaii, United States |
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| | Darmstadt University of Technology – Darmstadt, Germany |
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| | National Research Council Canada – Toronto, Ontario, Canada |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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Cancer Stem Cell News
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