 | | Vol. 13.34 – 1 September, 2022 |
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| It is currently accepted that cancer-associated fibroblasts participate in T cell exclusion from tumor nests. To unbiasedly test this, scientists used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that p53 expression increased gradually and reached maximal levels around eight days when laminin α4, α5, β2, β1, and γ1 subunit levels also reached a maximum during hepatic progenitor cell activation and expansion.
[Signal Transduction and Targeted Therapy] |
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| Researchers investigated the role of LIN28a in cartilage physiology and in osteoarthritis (OA). Lin28a-inducible conditional cartilage deletion up-regulated Mmp13 in intact mice and exacerbated the cartilage destruction in OA mice.
[Science Advances] |
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| An inflammation self-limiting fibrous tape was designed to restore inflammation self-limiting and promote tissue repair via regional immunity regulation.
[Small] |
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| Scientists proposed a novel method to fabricate an in situ mineralized homogeneous collagen-based scaffold with excellent osteogenic capability for guided bone regeneration by electrospinning the collagen solution in combination with essential mineral ions.
[Biofabrication] |
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| A myocardial matrix hydrogel was shown to have native capability as an effective reactive oxygen species scavenger and protected against oxidative stress-induced cell cycle inhibition in vitro.
[Acta Biomaterialia] |
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| The authors suggested that the dopamine-methacrylated hyaluronic acid hydrogel firmly adhered to the skin wound defect and promoted cell proliferation in vitro and skin defect regeneration in vivo.
[Cell Death & Disease] |
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| Investigators prepared a tissue-specific ECM-based bioink, and dECM/Gel/QCS 3D scaffold assembling with poly(ionic liquid)s was obtained by an extrusion 3D bioprinting technology and dynamic hydrogen bonding method.
[International Journal of Biological Macromolecules] |
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| Researchers evaluated the effect of a hydrogel conjugated angiopoietin-1 derived peptide hydrogel on human skin wound healing using a mouse xenograft model.
[Scientific Reports] |
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| Investigators explored the regulatory mechanism of circular RNA in the occurrence and development of urethral stricture.
[Scientific Reports] |
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| Scientists uncovered the underlying biochemical mechanisms controlling MST2 degradation and underscored how alterations in the microenvironment rigidity regulated the proteostasis of a central Hippo pathway component.
[Biochimica Et Biophysica Acta-General Subjects] |
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| Investigators provide the rational design criteria for predictably engineering hydrogels to mimic the properties of the natural ECM.
[Nature Reviews Chemistry] |
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| Scientists discuss the biomechanical properties of the bone matrix and their biological significance and summarize the compositional and structural basis by which the bone matrix is capable of exhibiting these mechanical properties.
[Bone Research] |
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| The authors introduce a 2D framework, termed the Biofilm Research-Industrial Engagement Framework (BRIEF) for classifying existing biofilm technologies according to their level of scientific insight, including the understanding of the underlying biofilm system.
[NPJ Biofilms and Microbiomes] |
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| Werewolf Therapeutics, Inc. announced that the first patient has been dosed in a Phase I/Ib clinical trial evaluating WTX-124, the company’s lead INDUKINETM molecule targeting IL-2 for the treatment of solid tumors.
[Werewolf Therapeutics, Inc.] |
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| November 10 – 12, 2022
Bordeaux, France |
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| | CRUK Manchester Institute – Manchester, England, United Kingdom |
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| | Stanford Medicine – Stanford, California, United States |
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| | National Research Council Canada – Toronto, Ontario, Canada |
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| | Darmstadt University of Technology – Darmstadt, Germany |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
