Lin28a Induces SOX9 and Chondrocyte Reprogramming via HMGA2 and Blunts Cartilage Loss in Mice

Scientists investigated the role of LIN28a in cartilage physiology and in osteoarthritis (OA). Lin28a-inducible conditional cartilage deletion up-regulated Mmp13 in intact mice and exacerbated the cartilage destruction in OA mice.