 | | Vol. 13.35 – 17 August, 2023 |
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| Researchers reported a dual nanoengineered DNA dynamic hydrogel developed through the supramolecular coassembly of amyloid fibrils and clay nanosheets with DNA strands.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that migrating fibroblasts deposit on the substrate a network of tubular structures that serves as a guidance cue for cancer cell migration. Such membranous tubular network, hereafter called tracks, was stably anchored to the substrate in a β5-integrin–dependent manner.
[Science Advances] |
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| A bioinformatics pipeline was used to identify the evolutionary relationships of bone ECM proteins. The analysis facilitated the identification of potential model organisms to study the molecular mechanisms of bone regeneration.
[Bone Research] |
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| Investigators compared biophysical properties of young versus proliferatively aged primary fibroblasts via fluorescence and traction force microscopy, single-cell atomic force spectroscopy, microfluidics, and microrheology of the cytoskeleton.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators presented a spatial multi-level physical-chemical and bio-inspired in situ bonding strategy, to develop a multifunctional hydrogel bio-glue using polyglutamic acid, tyramine hydrochloride, and tannic acid as precursors and DMTMM as condensation agent.
[Advanced Healthcare Materials] |
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| Researchers reported two distinct expression patterns of ASCL2 in proficient mismatch repair or microsatellite stable and deficient mismatch repair or microsatellite instability-high colorectal cancer.
[Oncogene] |
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| The authors found that SAM68 was transiently localized at the edge of spreading cells where it participated in membrane protrusive activity and the conversion of nascent adhesions to mechanically loaded focal adhesions by modulation of integrin signaling and local delivery of β-actin mRNA.
[eLife] |
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| Researchers investigated the therapeutic potential and underlying mechanisms of fraxinellone, a degraded limonoid isolated from the root bark of Dictamnus dasycarpus, in the treatment of intestinal fibrosis.
[Acta Pharmacologica Sinica] |
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| The authors reported the development of Matrisome AnalyzeR, a suite of tools including a web-based application and an R package. The web application could be used by anyone interested in annotating, classifying, and tabulating matrisome molecules in large datasets.
[Journal Of Cell Science] |
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| Researchers designed an antitumor compound named RCQ composed of resveratrol, curcumin, and quercetin. This study examined the effect on tumorigenesis and development of 4T1 breast cancer-bearing mice following administering RCQ by intragastric administration.
[Scientific Reports] |
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| Scientists described a completely defined, synthetic extracellular matrix that enabled co-culture of human endometrial epithelial and stromal cells in a manner that captured healthy and disease states across a simulated menstrual cycle.
[Med] |
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| The authors highlight approaches to examine ECM mechanics at tissue and cellular levels, focusing on how mechanical interactions between cells and the ECM regulate vascular phenotype, especially under certain pathological conditions.
[Nature Cardiovascular Research] |
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| Printer Bio-Implant company joined the RegeneratOR’s Innovation Accelerator in 2023, located in the Regenerative Medicine Hub, a rapidly growing regenerative medicine ecosystem based in the Innovation Quarter, in Winston-Salem.
[Brinter Bio-Implant (EurekAlert!)] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | The University of Copenhagen – Copenhagen, Denmark |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | National University of Singapore – Singapore, Singapore |
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