Extracellular Matrix News Volume 13.38 | Sep 29 2022

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    2022-09-29 | ECM 13.38


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.38 – 29 September, 2022
    TOP STORY

    Activated Natural Killer Cells-Dependent Dendritic Cells Recruitment and Maturation by Responsive Nanogels for Targeting Pancreatic Cancer Immunotherapy

    Researchers used tumor microenvironment responsive nanogels with prominent tumor-targeting capability by Panc02 cell membranes coating and inhibition of tumor-derived prostaglandin E2, aimed at improving natural killer cells activation, and inducing activated NK cells-dependent dendritic cells recruitment.
    [Small]

    Abstract

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    Strategy of a Cell-Derived Extracellular Matrix for the Construction of an Osteochondral Interlayer

    Scientists proposed that an ECM-derived from a suitable cell source might efficiently promote the formation of calcified cartilage.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Adipose Extracellular Matrix Deposition Is an Indicator of Obesity and Metabolic Disorders

    Multiple collagens, laminins, fibronectin, nidogen, and Hspg2 were upregulated in obese white adipose tissue from mice and humans.
    [Journal of Nutritional Biochemistry]

    Abstract

    IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function

    The authors developed a 4-arm poly(ethylene-glycol)-maleimide hydrogel functionalized with interleukin-10 to improve the local delivery and efficacy of a cell therapy against autoimmune disease.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Role of MMP3 and Fibroblast-MMP14 in Skin Homeostasis and Repair

    To identify the compensatory role of matrix metalloproteinase 3 (MMP3), mice were generated with MMP3 deletion in addition to MMP14 loss in fibroblasts.
    [European Journal of Cell Biology]

    Full Article

    Selenium-Sensitive Histone Deacetylase 2 Is Required for Forkhead Box O3A and Regulates Extracellular Matrix Metabolism in Cartilage

    Scientists explored the relationship between differentially expressed histone deacetylases and cartilage development, especially ECM homeostasis maintenance.
    [Journal of Bone and Mineral Metabolism]

    Abstract
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    REVIEWS

    Organization, Dynamics and Mechanoregulation of Integrin-Mediated Cell–ECM Adhesions

    Investigators review how the interplay of mechanical forces, biochemical signalling and molecular self-organization determines the composition, organization, mechanosensitivity and dynamics of these adhesions.
    [Nature Reviews Molecular Cell Biology]

    Full Article

    Matrix-Directed Mineralization for Bulk Structural Materials

    The authors provide a panoramic view of an emerging fabrication strategy, matrix-directed mineralization, which imitates the in vivo growth of some biominerals.
    [Journal of the American Chemical Society]

    AbstractGraphical Abstract

    Biomaterials and Tissue Engineering Approaches Using Glycosaminoglycans for Tissue Repair: Lessons Learned from the Native Extracellular Matrix

    Scientists provide an overview of native glycosaminoglycans, their structure, and their properties, specifically their interaction with proteins, their effect on cell behavior, and their mechanical role in the ECM.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    MIT Biologist Richard Hynes Wins Lasker Award

    MIT Professor Richard Hynes, a pioneer in studying cellular adhesion, has been named a recipient of the 2022 Albert Lasker Basic Medical Research Award.
    [Massachusetts Institute of Technology]

    Press Release
    FEATURED EVENT

    Preclinical and Personalized Breast Cancer Research: Preclinical Models Course

    October 10 – 12, 2022
    Lausanne, Switzerland

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    JOB OPPORTUNITIES

    Research Officer – Mass Spectrometry Imaging

    Garvan Institute of Medical Research – Sydney, Australia

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Scientist – Regenerative Medicine in Atherosclerosis

    InVitro Cell Research, LLC – Fort Lee, New Jersey, United States

    PhD Student – Extracellular Matrix Architecture

    University Medical Center Freiburg – Freiburg, Germany

    PhD Student – Musculoskeletal Research Project

    University Hospital of Muenster – Münster, Germany

    > See All Jobs

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