Extracellular Matrix News Volume 13.40 | Oct 13 2022

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    2022-10-13 | ECM 13.40


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.40 – 13 October, 2022
    TOP STORY

    Collective Cell Migration during Optic Cup Formation Features Changing Cell-Matrix Interactions Linked to Matrix Topology

    By utilizing zebrafish optic cup formation, and combining novel transgenic lines and image analysis pipelines, investigators studied how ECM properties influenced cell migration in vivo.
    [Current Biology]

    AbstractGraphical Abstract
    ON1153CC-CPA-Liver Organoid_160 x 600_728 x 90
    PUBLICATIONSRanked by the impact factor of the journal

    Integrin-Based Adhesion Compartmentalizes ALK3 of the BMPRII to Control Cell Adhesion and Migration

    Scientists found that bone morphogenetic protein 2 (BMP2) stimulation controls the spatial organization of BMP receptors (BMPRs) by segregating ALK3 from BMPRII into β3 integrin-containing focal adhesions.
    [Journal of Cell Biology]

    Abstract

    Supramolecular Surface Coatings with Acetylated Polyrotaxane-Based Triblock Copolymers for Thermal Regulation of Cell Adhesion and Fabrication of Cell Sheets

    The adhesion, proliferation, morphology, and adhesion strength of NIH/3T3 cells on acetylated-polyrotaxanes (PRXs)-coated surfaces were found to be similar to those of the uncoated and unmodified PRX-coated surfaces.
    [Biomacromolecules]

    AbstractGraphical Abstract

    Fast Stress Relaxing Gellan Gum That Enhances the Microenvironment and Secreting Function of Bone Mesenchymal Stem Cells

    Human-derived bone marrow stem cells showed an enhanced release profile of growth factors and exosomes in the fast stress relaxing gellan gum hydrogel.
    [International Journal of Biological Macromolecules]

    Abstract

    Myosin 5b Is Required for Proper Localization of the Intermicrovillar Adhesion Complex in the Intestinal Brush Border

    Myosin 5b (MYO5B) is a molecular motor that traffics ion transporters to the apical membrane of enterocytes, and researchers tested to see if MYO5B may also be responsible for the localization of intermicrovillar adhesion complex proteins.
    [American Journal of Physiology-Gastrointestinal and Liver Physiology]

    Abstract

    Stem Cell Microencapsulation Maintains Stemness in Inflammatory Microenvironment

    Stem cell spheroid was encapsulated by interfacial assembly of metal-phenolic network nanofilm to form a stem cell microsphere capsule.
    [International Journal of Oral Science]

    Full ArticleGraphical Abstract

    A Hybrid Cartilage Extracellular Matrix-Based Hydrogel/Poly (ε-Caprolactone) Scaffold Incorporated with Kartogenin for Cartilage Tissue Engineering

    Beta cyclodextrin-modified alginate/cartilage ECM-based interpenetrating polymer network hydrogel was developed for sustained release of Kartogenin.
    [Journal of Biomaterials Applications]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Hydrogel Interfaces for Merging Humans and Machines

    The authors provide a comprehensive summary of functional modes, design principles, and current and future applications for hydrogel interfaces toward merging humans and machines.
    [Nature Reviews Materials]

    Abstract
    INDUSTRY AND POLICY NEWS

    NextCure Announces Initiation of Phase Ib/II Clinical Trial to Evaluate NC410 in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Immune Checkpoint Refractory or Naïve Solid Tumors

    NextCure, Inc. announced the initiation of a Phase Ib/II clinical trial to evaluate NC410 in combination with KEYTRUDA®, Merck’s anti-PD-1 therapy, in patients with immune checkpoint refractory or immune checkpoint naïve solid tumors.
    [NextCure, Inc.]

    Press Release
    FEATURED EVENT

    Frontiers in Cancer Science 2022

    November 7 – 9, 2022
    Singapore, Singapore

    > See All Events

    JOB OPPORTUNITIES

    PhD Student Positions – Tumor Ecosystem

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    PhD – Cartilage Organoids

    Eindhoven University of Technology – Eindhoven, Netherlands

    Faculty Position – Center for Genetic Disorders and Aging Research

    Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States

    Graduate Student – Nanomedicine and Chemical Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Officer – Mass Spectrometry Imaging

    Garvan Institute of Medical Research – Sydney, Australia

    > See All Jobs

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