Extracellular Matrix News Volume 13.42 | Oct 27 2022

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    2022-10-27 | ECM 13.42


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.42 – 27 October, 2022
    TOP STORY

    3D-Printed Prolamin Scaffolds for Cell-Based Meat Culture

    The prolamin scaffolds demonstrated good water stability and in vitro degradability due to the porous fiber surface, which was spontaneously generated by culturing muscle cells for one week.
    [Advanced Materials]

    Abstract
    ON987CXN-nov-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

    Investigators constructed a double-sided thermoresponsive mechanoactive hydrogel that combined good flexibility, self-healing, wet-tissue adhesion, and antibacterial functions.
    [ACS Nano]

    AbstractGraphical Abstract

    Matrix Metalloproteinase-7 Is Increased in Lung Bases but Not Apices in Idiopathic Pulmonary Fibrosis

    Lung tissue from idiopathic pulmonary fibrosis (IPF) bases were more fibrotic than in apices and MMP7 protein was elevated in IPF lung base tissue.
    [European Respiratory Journal]

    Full Article

    Bovine and Human Endometrium-Derived Hydrogels Support Organoid Culture from Healthy and Cancerous Tissues

    Scientists have developed hydrogels from decellularized human and bovine endometrium. They found that organoids grown in endometrial hydrogels were proteomically more similar to the native tissue than those cultured in Matrigel.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Hemicentin-Mediated Type IV Collagen Assembly Strengthens Juxtaposed Basement Membrane Linkage

    Researchers identified ECM proteins mediating a basement membrane (BM) linkage between the uterine utse and epidermal seam cell BMs in Caenorhabditis elegans that supports the uterus during egg-laying.
    [Journal of Cell Biology]

    Abstract

    The Extracellular Matrix Fibulin 7 Maintains Epidermal Stem Cell Heterogeneity during Skin Aging

    Fibulin 7 interacted with structural ECM and matricellular proteins, and the overexpression of fibulin 7 in primary keratinocytes resulted in slower proliferation and suppressed differentiation.
    [EMBO Reports]

    AbstractGraphical Abstract

    Effects of Extracellular Adhesion Molecules on Immune Cell Mediated Solid Tumor Cell Killing

    Researchers sought to determine the effects of extracellular adhesion provided by ECM of tumor microenvironment on immune cell cytotoxicity by devising microwell arrays coated with proteins either preventing or promoting cell adhesion.
    [Frontiers in Immunology]

    Full Article

    Role of Heparan Sulfate in Vasculogenesis of Dental Pulp Stem Cells

    The authors investigated the role of heparan sulfate in endothelial differentiation and vasculogenesis of dental pulp stem cells.
    [Journal of Dental Research]

    Abstract
    Five tips for returning to the lab after time off
    REVIEWS

    Matrix Metalloproteinases in Preterm Prelabor Rupture of Membranes in the Setting of Chorioamnionitis: A Scoping Review

    Scientists address the question of how MMP activity is associated with preterm prelabor rupture of membranes, particularly their induction due to sterile or nonsterile chorioamnionitis.
    [American Journal of Reproductive Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Biomedical Engineering Researcher Awarded Grant to Study Chronic Skin Fibrosis

    Wuertz-Kozak recently received more than $400,000 from the Congressional Directed Medical Research Program to investigate new therapeutic approaches for scleroderma, a chronic autoimmune disease that involves an overproduction of collagen, also referred to as fibrosis.
    [Rochester Institute of Technology]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

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    Ludwig Maximilians University of Munich – Munich, Germany

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    The University of Manchester – Manchester, England, United Kingdom

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    Institute of Hepatology, Foundation for Liver Research – London, United Kingdom

    PhD Student Positions – Tumor Ecosystem

    Luxembourg Institute of Health – Luxembourg, Luxembourg

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