Extracellular Matrix News Volume 13.43 | Nov 3 2022

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    2022-11-03 | ECM 13.43


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.43 – 3 November, 2022
    TOP STORY

    SUN2 Regulates Mitotic Duration in Response to Extracellular Matrix Rigidity

    The authors examined how ECM rigidity affected cell division and found that cells divided more rapidly when cultured on rigid substrates.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Artificial Extracellular Matrix Composed of Heparin-Mimicking Polymers for Efficient Anticoagulation and Promotion of Endothelial Cell Proliferation

    Scientists constructed artificial ECMs composed of heparin-mimicking polymers named GSAs and two typical cationic polymers, polyethyleneimine and chitosan, to investigate the anticoagulation and endothelialization of GSAs.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract

    The Synergistic Regulation of Chondrogenesis by Collagen-Based Hydrogels and Cell Co-Culture

    MSCs and chondrocytes were co-cultured or monocultured in collagen, CMA30 and CMA80 hydrogels in vitro or in vivo.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    A Decellularized Extracellular Matrix Derived from Keratinocytes Can Suppress Cellular Senescence Induced by Replicative and Oxidative Stresses

    Reconstituted ECMs were prepared by culturing keratinocytes at different passages using the decellularization technique
    [Biomaterials Science]

    AbstractGraphical Abstract

    Galangin Ameliorates Osteoarthritis Progression by Attenuating Extracellular Matrix Degradation in Chondrocytes via the Activation of PRELP Expression

    In vitro, galangin promoted ECM production and attenuated ECM degradation in human osteoarthritis chondrocytes.
    [European Journal of Pharmacology]

    Abstract

    Mesenchymal Stem Cells Promote Wound Healing and Effects on Expression of Matrix Metalloproteinases-8 and 9 in the Wound Tissue of Diabetic Rats

    The authors evaluated the therapeutic efficacy of human umbilical cord MSCs in a diabetic foot ulcer rat model. Wound healing was evaluated macroscopically every three days. In addition, they measured growth factors and specific proteins, MMP-9 and MMP-8.
    [Stem Cells and Development]

    Abstract

    Hyperglycemia with or without Insulin Resistance Triggers Different Structural Changes in Brain Microcirculation and Perivascular Matrix

    Researchers investigated the high fat-high sucrose feeding model and streptozotocin-induced type-1 diabetes mellitus model to study the early effects of hyperglycemia to demonstrate the brain microcirculatory changes, perivascular ECM alterations and 3D-reconstructed cleared brain tissues.
    [Metabolic Brain Disease]

    Abstract

    Extracellular Matrix Protein Gelatin Provides Higher Expansion, Reduces Size Heterogeneity, and Maintains Cell Stiffness in a Long-Term Culture of Mesenchymal Stem Cells

    Investigators found that cells on plates coated with ECM proteins had much higher proliferation compared to the regular tissue culture plates.
    [Tissue and Cell]

    Abstract

    Mesenchymal Stem Cells Encapsulation in Chitosan and Carboxymethyl Chitosan Hydrogels to Enhance Osteo-Differentiation

    Scientists designed and developed biocompatible and bioactive hydrogels for osteo-tissue regeneration based on the natural polysaccharide chitosan.
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    An Interdisciplinary Framework for the Characterization of Extracellular Matrix-Hydrogels for Biomedical Applications

    The authors critically discuss the tools to properly characterize ECM hydrogels, leading to an accurate roadmap to be applied in this field.
    [Matter]

    AbstractPress Release
    INDUSTRY AND POLICY NEWS

    Sanara MedTech and InfuSystem Announce Wound Therapy Partnership

    Sanara MedTech Inc. and InfuSystem Holdings, Inc. announced the establishment of a partnership, SI Wound Care, LLC, focused on delivering a complete wound care solution targeted at improving patient outcomes, lowering the cost of care, and increasing patient and provider satisfaction.
    [Sanara MedTech, Inc. (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

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    JOB OPPORTUNITIES

    Faculty Position – Regenerative Medicine

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Postdoctoral Position – Joint and Articular Cartilage Homeostasis

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Position – Advanced Tumoroid Biology

    Ludwig Maximilians University of Munich – Munich, Germany

    Postdoctoral Position – Oral Immunology and Tissue Degenerative Processes

    Umeå, Sweden – Umeå University

    PhD Studentships – Cancer Research

    The University of Manchester – Manchester, England, United Kingdom

    > See All Jobs

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