 | | Vol. 13.46 – 24 November, 2022 |
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| Using the murine model, in vitro systems, and patient samples, scientists showed that hyperglycemia increased tumor growth, ECM stiffness, glycation, and epithelial-mesenchymal transition of tumor cells.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers presented that platelet endothelial aggregation receptor 1 (PEAR1) in fibroblasts may serve as a target for pulmonary fibrosis therapy.
[Nature Communications] |
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| While tumor cells were unable to exploit collagen directly, here the authors showed they can usurp metabolic byproducts of collagen-consuming tumor-associated stroma.
[Nature Communications] |
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| Researchers compared the tumor biological behaviors of nasopharyngeal carcinoma cells in 2D, on-surface 3D and embedded 3D systems, and investigated the correlation between radioresistance and ECM stiffness.
[Cancer Cell International] |
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| Investigators found that neutrophil extracellular traps (NETs) could promote the apoptosis of human amniotic epithelial cells via ERK1/2 pathways dependent on reactive oxygen species (ROS) release.
[Journal of Reproductive Immunology] |
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| Scientists reported that 3D cell culture of dermal fibroblasts promoted secretion of exosomes carrying a large quantity of proteins involved in the formation, organisation and remodelling of the extracellular matrix.
[Scientific Reports] |
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| The authors studied the expression of the major extracellular matrix proteins of fibrosis in relation to diagnostic silver grading supported by image analysis.
[Histopathology] |
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| Investigators evaluated the effects on the overexpression of periostin, POSTN a regulator ECM protein, in myometrial cells.
[Reproductive Sciences] |
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| The protective effects of oleracone C isolated from Portulaca olerace against ultraviolet B (UVB)-induced changes in MMPs and type I procollagen production were investigated in human keratinocytes.
[International Journal of Cosmetic Science] |
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| Researchers investigated the interplay between heparan sulfate degradation and radiation response in triple-negative breast cancer cells.
[Archives of Medical Research] |
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| Scientists systematically compared the effect of two ECM classes, the interstitial matrix and the basement membrane, on the intestinal epithelium. They found that both collagen I and laminin-containing cultures allowed growth of small intestinal epithelial cells with all cell types present in both cultures.
[Biology Open] |
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| The authors analyze the current research advances on matrix stiffness and tumor cell behavior with a view to contributing to tumor cell growth and treatment, with the hope of improving the understanding of the biological role of matrix stiffness in tumors.
[Journal of Translational Medicine] |
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| Biocept, Inc. announced a collaboration agreement to participate in an investigator-initiated, non-therapeutic pilot study to evaluate the cerebrospinal fluid tumor and immune cell microenvironment in patients with metastatic breast cancer and brain metastases and/or leptomeningeal disease.
[Biocept, Inc.] |
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| January 29 – February 2, 2023
Banff, Alberta, Canada |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Biosynth – Lelystad, Netherlands |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
