Extracellular Matrix News Volume 13.47 | Dec 1 2022

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    2022-12-01 | ECM 13.47


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.47 – 1 December, 2022
    TOP STORY

    Matrix Viscoelasticity Controls Spatiotemporal Tissue Organization

    Scientists showed that the passive viscoelastic properties of the matrix encapsulating a spheroidal tissue of breast epithelial cells guided tissue proliferation in space and in time.
    [Nature Materials]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Matrix Secretion Mechanically Reinforces Interlocking Interfaces

    Interlocked flocked scaffolds improved cell survivorship under mechanical compression and sustained cell viability and proliferation. Additionally, the compression and shearing resistance of cell-seeded interlocking interfaces increased with increasing ECM deposition.
    [Advanced Materials]

    Abstract

    3D ECM-Rich Environment Sustains the Identity of Naive Human iPSCs

    Using an unbiased and integrated approach combining microfluidic cultures with transcriptional, proteomic, and secretome analyses, researchers found that naive, but not primed, human induced pluripotent stem cell (iPSC) colonies were characterized by a self-organized ECM-rich microenvironment.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Thrombospondin 1 Missense Alleles Induce Extracellular Matrix Protein Aggregation and TM Dysfunction in Congenital Glaucoma

    Investigators identified heterozygous thrombospondin 1 missense alleles altering p.Arg1034 in three unrelated and ethnically diverse families affected by congenital glaucoma, a severe form of glaucoma affecting children.
    [Journal of Clinical Investigation]

    Full ArticlePress Release

    Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation

    Researchers described that multiple acetyl-vWA domain-carrying proteins including integrin β3 and collagen 6A were deacetylated by Sirtuin family member SIRT2 in extracellular space.
    [Advanced Science]

    Full Article

    Extracellular Matrix Profiles Determine Risk and Prognosis of the Squamous Cell Carcinoma Subtype of Non-Small Cell Lung Carcinoma

    Scientists revealed subtype-specific ECM signatures associated with tumor initiation that were predictive of premalignant progression.
    [Genome Medicine]

    Full ArticlePress Release

    Broadly Applicable Hydrogel Fabrication Procedures Guided by YAP/TAZ-Activity Reveal Stiffness, Adhesiveness, and Nuclear Projected Area as Checkpoints for Mechanosensing

    Protocols were streamlined for the synthesis and functionalization of cell adhesive polyacrylamide-based and fully-defined polyethyleneglycol-based hydrogels tuned at various rigidities for mechanobiology experiments, from 0.3 to >10 kPa.
    [Advanced Healthcare Materials]

    Full Article

    Extracellular Matrix Drives Tumor Organoids toward Desmoplastic Matrix Deposition and Mesenchymal Transition

    The authors combined cholangiocarcinoma organoids with native tumor and liver scaffolds, obtained by decellularization, to effectuate a model to study the interaction between epithelial tumor cells and their surrounding ECM.
    [Acta Biomaterialia]

    Abstract

    Predicting YAP/TAZ Nuclear Translocation in Response to ECM Mechanosensing

    Scientists extended a previously developed a computational model to more general ECM behaviors and included more details about YAP/TAZ translocation dynamics based on nuclear deformation.
    [Biophysical Journal]

    Abstract

    Atorvastatin Induces Downregulation of Matrix Metalloproteinase-2/9 in MDA-MB-231 Triple Negative Breast Cancer Cells

    Researchers confirmed the apoptotic activity of atorvastatin on highly metastatic MDA-MB-231 triple-negative breast cancer cells and investigated the gene expression of MMP-2/9.
    [Medical Oncology]

    Abstract
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    REVIEWS

    Bone/Cartilage Targeted Hydrogel: Strategies and Applications

    Investigators summarize the bone-targeted hydrogel through application environment, construction strategies, and disease applications in order to provide a reference for the development of bone-targeted hydrogels.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Exploring the Cardiac ECM during Fibrosis: A New Era with Next-Gen Proteomics

    The authors summarize the role of different ECM components during cardiac fibrosis progression leading to heart failure and highlight the importance of applying mass-spectrometry-based proteomics to understand the key changes occurring in the ECM during fibrotic progression.
    [Frontiers in Molecular Biosciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    Pyxis Oncology Announces FDA Clearance of Two IND Applications

    Pyxis Oncology, Inc. announced that it has received clearance for its two Investigational New Drug (IND) applications from the US FDA to initiate Phase I clinical trials. The trials of PYX-201 and PYX-106 will evaluate the safety and anti-tumor activity in patients with select solid tumors.
    [Pyxis Oncology, Inc.]

    Press Release
    FEATURED EVENT

    Drug Delivery to the Brain: Challenges and Progress

    January 23 – 25, 2023
    Breckenridge, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant Professor – Lung Cancer Dissemination

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Researcher – Microtechnologies for Organoids

    Roche – Basel, Switzerland

    Postdoctoral Fellow – Organ-on-Chip Systems

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Fellow – Cancer Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    PhD Student – Cell-Adhesive Peptides

    Biosynth – Lelystad, Netherlands

    > See All Jobs

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