Extracellular Matrix News Volume 13.48 | Dec 8 2022

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    2022-12-08 | ECM 13.48


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.48 – 8 December, 2022
    TOP STORY

    Bone ECM-Like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

    Investigators developed a facile approach to fabricate a bionic scaffold perfectly combining bone ECM-like microenvironment and robust mechanical properties.
    [ACS Nano]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Matrix Sheet Modified with VEGF-Loaded Nanoparticles for Bladder Regeneration

    ECM bioscaffolds were derived from decellularized sheets and then modified with vascular endothelial growth factor (VEGF)-conjugated superparamagnetic iron oxide nanoparticles to promote angiogenesis.
    [NPG Asia Materials]

    Full Article

    Fibroblasts Repair Blood-Brain Barrier Damage and Hemorrhagic Brain Injury via TIMP2

    By targeting Col1α1, scientists generated mice with ablated Col1α1+ fibroblasts. These mutants showed exacerbated blood-brain barrier damage, enlarged injury volume, and worse neurological function, highlighting a beneficial role of Col1α1+ fibroblasts in intracerebral hemorrhage.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Amyloid-Based Albumin Hydrogels

    The authors presented the formation of physically cross-linked, self-healing hydrogels based on bovine serum albumin at room temperature through a straightforward disulfide reduction step induced by tris (2-carboxyethyl) phosphine hydrochloride.
    [Advanced Healthcare Materials]

    Abstract

    3D Printed Multi-Growth Factor Delivery Patches Fabricated Using Dual-Crosslinked Decellularized Extracellular Matrix-Based Hybrid Inks to Promote Cerebral Angiogenesis

    Scientists developed a 3D printed spatiotemporally compartmentalized cerebral angiogenesis inducing hydrogel patch, releasing dual angiogenic growth factors, using extracellular matrix-based hybrid inks.
    [Acta Biomaterialia]

    Abstract

    Cross-Talk between TSC2 and the Extracellular Matrix Controls Pulmonary Vascular Proliferation and Pulmonary Hypertension

    ECM produced by tuberous sclerosis complex 2 (TSC2)-deficient pulmonary artery vascular smooth muscle cells (PAVSMCs) stimulated the proliferation of nondiseased PA adventitial fibroblasts and PAVSMCs through fibronectin and its receptor.
    [Science Signaling]

    Abstract

    Laminin Matrix Adhesion Regulates Basal Mammary Epithelial Cell Identity

    Researchers showed that adhesion of basal cells to laminin α5-containing basement membrane matrix, which was produced by luminal cells, presented a regulated control mechanism to restrict excess basal cell activity.
    [Journal of Cell Science]

    Abstract

    Heterogeneous Matrix Stiffness Regulates the Cancer Stem-Like Cell Phenotype in Hepatocellular Carcinoma

    Investigators provided new insights into the interaction between matrix stiffness, cancer cell stemness, and heterogeneity, while also providing a novel hepatocellular carcinoma therapeutic strategy.
    [Journal of Translational Medicine]

    Full Article

    Matrix Metalloproteinase 1 as a Marker of Tonsil-Derived Mesenchymal Stem Cells to Assess Bone Marrow Cell Migration

    To examine the donor-to-donor variation of tonsil-derived mesenchymal stem cells (TMSCs) in potentiating bone marrow cells migration, the authors isolated TMSCs from 25 independent donors.
    [Tissue Engineering and Regenerative Medicine]

    Abstract

    Micromechanical Property Mismatch between Pericellular and Extracellular Matrices Regulates Stem Cell Articular and Hypertrophic Chondrogenesis

    Researchers reported a unique biomaterial-based engineering strategy to create cartilage-tissue equivalents possessing pericellular matrix (PCM)-ECM microarchitecture of native cartilage.
    [Matter]

    AbstractGraphical Abstract
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    REVIEWS

    Advances in Biomimetic Collagen Mineralisation and Future Approaches to Bone Tissue Engineering

    Scientists sum up the current understanding of bone tissue mineralization and structure while providing a critical outlook on the existing biomimetic strategies of mineralizing collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.
    [Biopolymers]

    Full Article
    INDUSTRY AND POLICY NEWS

    Postdoc Union Reaches Tentative Agreement with University of California

    After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.
    [Science Careers]

    Press Release
    FEATURED EVENT

    DDR Inhibitors Summit 2023

    January 24 – 26, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Liver Metastasis of Colorectal Cancer

    Karolinska Institute – Solna, Sweden

    Postdoctoral Scientist – Cardiovascular Sciences

    Duke University – Durham, North Carolina, United States

    Tenure Track Positions – Precision Oncology and Immuno-Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Research Assistant Professor – Lung Cancer Dissemination

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Researcher – Microtechnologies for Organoids

    Roche – Basel, Switzerland

    > See All Jobs

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