 | | Vol. 13.49 – 15 December, 2022 |
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| In vivo, single intrasplenic injection of degrading liver sinusoidal endothelial cells (dLSECs) alleviated advanced liver fibrosis in mice, while intraperitoneal administration of liver-targeting peptide-modified dLSECs showed enhanced fibrosis-targeting effects.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a responsively reversible and asymmetrically adhesive Janus hydrogel that enabled on-demand stimuli-triggered detachment for efficient myocardial infarction repair.
[Nature Communications] |
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| Investigators reported that a three-dimensional microenvironment reconstituted with decellularized heart ECM could enhance chemical reprogramming and cardiac maturation of fibroblasts to cardiomyocytes.
[Science Advances] |
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| Researchers described the culture of multiple prostate cancer-derived PDX models as 3D clusters within engineered biomimetic hydrogel matrices alongside bone marrow-derived stromal cells and a perfused endothelial channel.
[Advanced Healthcare Materials] |
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| A biomaterial system composed of two-dimensional mechano-variant silicone substrates with simplified and scalable surface biofunctionalization chemistry was developed to facilitate large-scale cell culture expansion processes.
[Advanced Healthcare Materials] |
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| The authors reported how individual modules of the senescence program differentially influenced cell mechanics and ECM expression with relevance for tissue formation.
[Aging Cell] |
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| The ECM obtained using this first iteration of a unified protocol was able to produce ECM hydrogels from skin, lung, muscle, tendons, cartilage, and laryngeal tissues.
[Biomaterials Science] |
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| Scientists showed the use of synthetic glycosaminoglycans for controlled binding and release of growth factors to induce a desired cellular response.
[Communications Biology] |
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| Researchers studied the endothelium–collagen interactions mediated by the collagen-binding integrins, α1β1, α2β1, α10β1, and α11β1 expressed in human umbilical vein endothelial cells.
[Scientific Reports] |
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| The authors outline the importance and challenges of creating hydrogels that mimic the mechanical and biological properties of the native ECM.
[Nature Reviews Methods Primers] |
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| Scientists discuss tumor microenvironment-associated aspects with an emphasis on T cell trafficking, extracellular matrix barriers, abnormal vasculature, solid tumor heterogenicity, and immune suppressive microenvironment.
[Clinical and Translational Medicine] |
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| Investigators review the effects of various ECM components on synapse formation and briefly describe the related diseases caused by the abnormality of several ECM components.
[Bioscience Reports] |
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| Cancer translational scientist Keith Syson Chan, Ph.D., has joined Houston Methodist thanks to a $6 million Established Investigator recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT).
[Houston Methodist] |
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| The US National Institutes of Health (NIH) has released a tentative plan to change how its research grant applications are scored, with the aim of reducing bias and lowering the burden on reviewers.
[Nature] |
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| February 12 – 15, 2023
Santa Fe, New Mexico, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | Karolinska Institute – Solna, Sweden |
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| | Duke University – Durham, North Carolina, United States |
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Cancer Stem Cell News
Cell Therapy News
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