 | | Vol. 14.02 – 19 January, 2023 |
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| Investigators revealed that increased matrix stiffness was associated with poor responses to neoadjuvant chemotherapy, worse prognosis, and cancer stem cell enrichment in patients with breast cancer.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The concept of extrafibrillar demineralization was introduced into the construction of dentin-derived biomaterials for bone regeneration for the first time.
[Advanced Healthcare Materials] |
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| Scientists investigated how human bone-marrow-derived mesenchymal stem cells differentiated into early osteoblasts on a soft three-dimensional hydrogel.
[Advanced Healthcare Materials] |
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| Researchers investigated whether and how matrix remodeling associated 7 (MXRA7) participated in cutaneous wound healing. An ear-punching model was utilized in wild-type and MXRA7-deficient mice, and the dermal fibroblasts from these mice were further studied in vitro.
[Inflammation and Regeneration] |
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| Investigators reported a peptide scaffold cell-culture-medium additive for mimicking in vivo ECM to enhance the storage efficiency of mesenchymal stem cells under hypothermic preservation.
[ACS Applied Materials & Interfaces] |
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| In vitro results demonstrated that fibrin-enriched cardiac ECM hydrogels could induce robust endothelial cell tube formation from human umbilical vein endothelial cells and promote the sprouting of human mesenchymal stem cell spheroids.
[ACS Biomaterials Science & Engineering] |
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| Researchers developed a 3D multifunctional bi-layer scaffold composed of a kartogenin (KGN)-loaded GelMA hydrogel as an upper layer mimicking a cartilage-specific ECM, and a hydroxyapatite-coated 3D printed polycaprolactone porous scaffold as a lower layer simulating subchondral bone.
[Journal of Materials Chemistry B] |
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| Scientists assessed how changes in matrix composition and stiffness influenced hepatocellular carcinoma (HCC) tumor behavior. HCC-cell lines were grown in a biomimetic hydrogel model resembling the stiffness and composition of a fibrotic or cirrhotic liver.
[Scientific Reports] |
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| Injectable Aldehyde-cellulose nanocrystalline/silk fibroin hydrogels containing polyetheretherketone were synthesized, and their bone regeneration capacity was evaluated.
[Scientific Reports] |
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| Mechanistic hypotheses are presented to address the impact of the ECM properties and their changes with aging on Alzheimer’s disease (AD) and AD-related dementias.
[Advanced Science] |
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| The authors document the role of collagen in bone tissue engineering, focusing on collagen type I, its crosslinking capability, collagen-based biomaterials, and fabrication methods.
[Applied Biochemistry and Biotechnology] |
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| New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
[ScienceInsider] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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| | BioMed X Institute – New Haven, Connecticut, United States |
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| | The University of Southern Denmark – Odense, Denmark |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
Extracellular Matrix News
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Hepatic Cell News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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Neural Cell News
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