Extracellular Matrix News Volume 14.04 | Feb 2 2023

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    2023-02-02 | ECM 14.04


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.04 – 2 February, 2023
    TOP STORY

    Lysyl Hydroxylase LH1 Promotes Confined Migration and Metastasis of Cancer Cells by Stabilizing Septin2 to Enhance Actin Network

    Liquid chromatography-mass spectrometer was applied to determine the differentially expressed proteins between hepatocellular carcinoma tissues and corresponding adjacent tissue.
    [Molecular Cancer]

    Full Article
    Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    ECM-Inspired Hydrogels with ADSCs Encapsulation for Rheumatoid Arthritis Treatment

    Scientists proposed a novel ECM-inspired injectable hydrogel for adipose-derived stem cells (ADSCs) encapsulation and rheumatoid arthritis treatment.
    [Advanced Science]

    Full Article

    Development and Evaluation of a Low-Cost LEGO 3D Bioprinter: From Building-Blocks to Building Blocks of Life

    Investigators demonstrated construction of a benchtop LEGO 3D bioprinter for additive layer manufacture of a 3D structure containing viable human skin cells within a hydrogel scaffold.
    [Advanced Materials Technologies]

    Full Article

    Macrophage-Derived GPNMB Trapped by Fibrotic Extracellular Matrix Promotes Pulmonary Fibrosis

    The macrophage-derived glycoprotein nonmetastatic melanoma protein B captured by fibrotic ECM might activate resident normal fibroblasts around the fibrotic foci.
    [Communications Biology]

    Full Article

    Indole-3-Propionic Acid Alleviates Chondrocytes Inflammation and Osteoarthritis via the AhR/NF-κB Axis

    IL-1β was utilized to induce chondrocyte inflammation. The cytotoxicity of indole-3-propionic acid on rat chondrocytes was assessed. RT-qPCR, Griess reaction, ELISA, Western blot, and immunofluorescence were performed to evaluate the expression of inflammatory factors and stromal proteins.
    [Molecular Medicine]

    Full Article

    Intra-Corneal Implantation of 3D Bioprinted Scaffolds Containing Mesenchymal Stromal Cells using Femtosecond-Laser-Assisted Intrastromal Keratoplasty

    Ex vivo cultured, mesenchymal stem cell-loaded 3D bioprinted structures remained intact, supported cell survival and contained de novo synthesized extracellular matrix components and migrating cells throughout the observation period.
    [Macromolecular Bioscience]

    Abstract

    Lung Macrophages Utilize Unique Cathepsin K–Dependent Phagosomal Machinery to Degrade Intracellular Collagen

    Using a quantitative proteomics approach, researchers identified cathepsins as key determinants of phagosome maturation in primary peritoneum-, lung-, and brain-resident macrophages.
    [Life Science Alliance]

    Full Article

    Different Decellularization Methods in Bovine Lung Tissue Reveals Distinct Biochemical Composition, Stiffness, and Viscoelasticity in Reconstituted Hydrogels

    Investigators established bovine lung tissue decellularization for the first time via pursuing four different protocols and characterization of reconstituted decellularized lung ECM hydrogels for biochemical and mechanical properties.
    [ACS Applied Bio Materials]

    Full ArticleGraphical Abstract

    Igf1 Regulates Fibrocartilage Stem Cells, Cartilage Growth, and Homeostasis in the Temporomandibular Joint of Mice

    The authors investigated the functional role of Igf1 in fibrocartilage stem cells for temporomandibular jointcartilage growth and homeostasis by lineage tracing using Gli1-CreER+; Tmflfl mice and conditional Igf1 deletion using Gli1-/Col2-CreER+; Igf1fl/fl mice.
    [Journal Of Bone And Mineral Metabolism]

    Abstract

    Differentiation of Human Spermatogonial Stem Cells Using a Human Decellularized Testicular Scaffold Supplemented by Platelet-Rich Plasma

    Spermatogonial stem cells were cultured on the human decellularized testicular matrix for four weeks. The viability and the expression of differentiation genes were evaluated by MTT and real-time PCR, respectively.
    [Artificial Organs]

    Abstract
    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    Metabolic Reprogramming Heterogeneity in Chronic Kidney Disease

    Emerging evidence suggests that alterations in metabolism are not only a feature of but also play an influential role in the pathogenesis of renal fibrosis.
    [FEBS Open Bio]

    Abstract
    INDUSTRY AND POLICY NEWS

    NHLBI Funds Bae’s Continuing Research on Arterial Stiffness

    Dr. Yongho Bae, assistant professor of pathology and anatomical sciences, has been awarded a five-year, $2.9 million grant from the National Heart, Lung and Blood Institute to continue his research into the effects of arterial stiffness on cardiovascular disease.
    [University of Buffalo]

    Press Release

    FEATURED EVENT

    The Aging Genome: From Mechanisms to Disease

    June 4 – 7, 2023
    Heidelberg, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Therapeutic Resistance, Tumor Dormancy and Metastasis

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Staff Scientist – Genetics and Epigenetics of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    PhD Student – Computational Oncology

    Essen University Hospital – Essen, Germany

    Scientist/Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    Research Technician – 3DVasCMD

    European Molecular Biology Laboratory – Barcelona, Spain

    > See All Jobs

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