Extracellular Matrix News Volume 14.06 | Feb 16 2023

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    2023-02-16 | ECM 14.06


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.06 – 16 February, 2023
    TOP STORY

    Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and ts Application in Wound Healing

    The authors demonstrated the use of an injectable fibro-gel, a water-filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles could be tailored to overcome various shortcomings.
    [Advanced Materials]

    Abstract
    ON1058PSC-ISSCR Innovation Showcase Webinars Set 1_final 300 x 250 A
    PUBLICATIONSRanked by the impact factor of the journal

    Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury

    A strategy to fabricate PDGF-MP hydrogel microspheres instead of bulk hydrogels was proposed to dramatically enhance the efficiency of platelet-derived growth factor mimetic peptide in activating its receptor.
    [ACS Nano]

    AbstractGraphical Abstract

    Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention

    Researchers designed and synthesized advanced injectable cream-like hydrogels with multiple functionalities, including rapid gelation, self-healing, antioxidation, anti-inflammation, and anti-cell adhesion.
    [ACS Nano]

    Full ArticleGraphical Abstract

    Effects of Biomechanical and Biochemical Stimuli on Angio- and Vasculogenesis in a Complex Microvasculature-on-Chip

    The authors presented a microvasculature-on-chip model to investigate the singular effect of ECM stiffness and mechanical cyclic stretch on vascular development.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs

    Using an optimized three-step decellularization and ECM extraction method involving chaotrope extraction and digestion via hydroxylamine hydrochloride, researchers generated coverage of the matrisome across 25 organs.
    [Journal Of Proteome Research]

    AbstractGraphical Abstract

    Heparin-Based Sericin Hydrogel–Encapsulated Basic Fibroblast Growth Factor for In Vitro and In Vivo Skin Repair

    Investigators designed a heparin-based sericin hydrogel-encapsulated basic fibroblast growth factor to facilitate wound healing and skin regeneration.
    [Heliyon]

    Full Article

    Mapping the 3D Remodeling of the Extracellular Matrix in Human Hypertrophic Scar by Multi-Parametric Multiphoton Imaging Using Endogenous Contrast

    The authors performed label-free multiphoton microscopy of both fiber components from human skin specimens and propose a multi-fiber metrics analysis model for mapping the structural remodeling of the ECM in hypertrophic scars in a highly-sensitive, 3D manner.
    [Heliyon]

    Full Article

    A Delivery System into the Dermis Layer of Skin Using Small Unilamellar Liposomes and Targeted Collagen Regeneration Stimulated by Electric Field

    Understanding that various factors can influence collagen assembly, scientists studied the effect of electric field exposure and visualized collagen fibrils’ fibrillogenesis process under the confocal microscope
    [Biophysical Journal]

    Abstract

    A Novel Liposomal Cellular Model, Complexed with Extracellular Matrix

    By making phospholipid liposomes bound with ECM, it was possible to generate stable liposomes despite rapid changes in osmotic pressure or external physical stimuli.
    [Biophysical Journal]

    Abstract
    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    Immunogenicity of Decellularized Extracellular Matrix Scaffolds: A Bottleneck in Tissue Engineering and Regenerative Medicine

    Scientists discuss the interplay between damage-associated molecular patterns and antigens as the main inducers of innate and adaptive immunity to aid in manufacturing biocompatible grafts with desirable immunogenicity.
    [Biomaterials Research]

    Full Article

    Cartilage Extracellular Matrix-Derived Matrikines in Osteoarthritis

    A better understanding of the matrikine landscape occurring with or even preceding obvious degenerative changes in joint tissues is needed and might help to identify molecules that could serve as biomarkers, druggable targets, or even be blueprints for disease-modifying drug osteoarthritis drugs.
    [American Journal Of Physiology-Cell Physiology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Three Yale Scholars Win Prestigious Sloan Fellowships

    The three Yale honorees — Roy Lederman, assistant professor of statistics and data science, Lidya Tarhan, assistant professor of Earth and planetary sciences, and Jing Yan, assistant professor of molecular, cellular and developmental biology — will each receive two-year, $75,000 fellowships.
    [Yale]

    Press Release
    FEATURED EVENT

    Oxford Vascular Biology Symposium 2023

    March 27, 2023
    Oxford, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    PhD Project – Polymer-Protein Interaction

    Loughborough University – Leicestershire, England, United Kingdom

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    Postdoctoral Researcher – Neuroimaging and Biomarkers of Inflammation

    A University of the Basque Country – Leioa, Spain

    Postdoctoral Research Fellow – Therapeutic Resistance, Tumor Dormancy, and Metastasis

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Staff Scientist – Genetics and Epigenetics of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    > See All Jobs

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