Extracellular Matrix News Volume 14.08 | Mar 2 2023

    By
    lbeveridge
    -
    0
    38








    2023-03-01 | ECM 14.08


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.08 – 2 March, 2023
    TOP STORY

    Molecular Tuning of a Benzene-1,3, 5-Tricarboxamide Supramolecular Fibrous Hydrogel Enables Control over Viscoelasticity and Creates Tunable ECM-Mimetic Hydrogels and Bioinks

    Scientists reported the molecular tuning of a self-assembling, supramolecular benzene-1,3,5-tricarboxamide hydrogelator via simple modulation of hydrophobic substitutents.
    [Advanced Materials]

    Abstract
    728x90_2023Z1-KSMetastasis23
    PUBLICATIONSRanked by the impact factor of the journal

    Reproducing Extracellular Matrix Adverse Remodeling of Non-ST Myocardial Infarction in a Large Animal Model

    The authors developed an ovine model of non-ST-segment elevation myocardial infarction by ligating the myocardial muscle at precise intervals parallel to the left anterior descending coronary artery.
    [Nature Communications]

    Full ArticlePress Release

    De Novo Tissue Formation Using Custom Microporous Annealed Particle Hydrogel Provides Long-Term Vocal Fold Augmentation

    Researchers developed a novel iteration of microporous annealed particle scaffold designed to provide persistent augmentation.
    [NPJ Regenerative Medicine]

    Full Article

    A Zeb1/MtCK1 Metabolic Axis Controls Osteoclast Activation and Skeletal Remodeling

    While attempting to identify new regulatory molecules critical to bone resorption, scientists discovered that murine and human osteoclast differentiation was accompanied by the expression of Zeb1, a zinc-finger transcriptional repressor.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Temporal Application of Lysyl Oxidase during Hierarchical Collagen Fiber Formation Differentially Effects Tissue Mechanics

    Investigators developed a culture system which guided cells in high-density collagen gels to develop native-like hierarchically organized collagen fibers, which matched native fiber alignment and diameters by six weeks.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    TGF-β in the Microenvironment Induces a Physiologically Occurring Immune-Suppressive Senescent State

    The authors showed that TGF-β induced a deeper senescent state under hypoxia than under normoxia; deep senescence correlated with the degree of E2F suppression and was marked by multinucleation, reduced reentry into proliferation, and a distinct 14-gene senescence-associated secretory phenotype.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Matrix Stiffness Induces Epithelial-to-Mesenchymal Transition Via Piezo1-Regulated Calcium Flux in Prostate Cancer Cells

    Researchers expanded on the understanding of how epithelial-to-mesenchymal transition was controlled via the mechanosensitive calcium channel Piezo1 in cancerous cells, which sensed changes in the extracellular matrix stiffness.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal Cancer-Associated Fibroblasts in Glioblastoma with Protumoral Effects

    Cells without copy number variations and with high cancer-associated fibroblasts (CAF) probability scores were identified in single-cell RNA-Seq of 12 patient glioblastomas. Pseudotime reconstruction revealed that immature CAFs evolved into subtypes, with mature CAFs expressing actin alpha 2, smooth muscle.
    [Journal Of Clinical Investigation]

    Full Article

    Long-Term Ultrasonographic and Histologic Changes in Acellular Dermal Matrix in Implant-Based Breast Reconstructions

    Investigators evaluated the US results of 144 patients who underwent implant-based breast reconstructions with acellular dermal matrix (ADM) coverings. The US results obtained within 18 months of surgery and those obtained 5 years postoperatively were analyzed to determine the change in the ADM thickness.
    [Plastic And Reconstructive Surgery]

    Abstract

    Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(lactic Acid)/Ti6Al4V Composite Scaffold with Plasma Treatment Modification

    Utilizing a material extrusion technique, 3 PLA-Ti6Al4V scaffolds with open pores and interconnected channels were successfully fabricated.
    [Scientific Reports]

    Full Article

    Antibacterial and Antioxidant Double-Layered Nanofibrous Mat Promotes Wound Healing in Diabetic Rats

    A double-layered nanofibrous mat containing grape seed extract and silver sulfadiazine was fabricated. A synthetic biodegradable polymer, eg, polycaprolactone, and a natural material were employed as wound dressing substances.
    [Scientific Reports]

    Full Article

    CD206+ Tendon Resident Macrophages and Their Potential Crosstalk with Fibroblasts and the ECM during Tendon Growth and Maturation

    Fluorescent imaging of cryosections revealed that F4/80+ tendon resident macrophages resided adjacent to Col1a1-CFP+ Scx-GFP+ fibroblasts within the tendon fascicle from embryonic development into adulthood.
    [Frontiers In Physiology]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    Cell–Extracellular Matrix Mechanotransduction in 3D

    The authors discuss recent progress in our understanding of cell–extracellular matrix mechanotransduction in 3D.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    The Factory, the Antenna, and the Scaffold: The Three-Way Interplay between the Golgi, Cilium and Extracellular Matrix Underlying Tissue Function

    Scientists examine how the interplay between all three compartments underpins healthy tissue. They look at several members of the golgin family of Golgi-resident proteins whose loss is detrimental to connective tissue function.
    [Biology Open]

    Full Article
    INDUSTRY AND POLICY NEWS

    Genascence Receives $11.6 Million Award From California Institute for Regenerative Medicine to Help Advance its Lead Gene Therapy Program in Knee Osteoarthritis

    Genascence Corporation announced it has been awarded $11.6 million over four years from the California Institute for Regenerative Medicine. The funding will be used to support Genascence’s Phase 1b clinical trial of GNSC-001 in knee osteoarthritis, as well as phase-appropriate manufacturing activities.
    [Genascence Corporation (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    Vascular Inflammation and the ECM

    April 20 – 21, 2023
    Sheffield, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Regenerative Medicine & the ECM

    InVitro Cell Research, LLC – Fort Lee, New Jersey, United States

    Lecturer – Cell Matrix Research

    The University of Manchester – Manchester, England, United Kingdom

    Postdoctoral Researcher – Type III Collagen

    Penn Medicine – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Cartilage Regeneration

    University Medical Center Utrecht – Utrecht, Netherlands

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Extracellular Matrix News Twitter