 | | Vol. 14.10 – 16 March, 2023 |
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| Over time, hallmark glioblastoma genes were not significantly altered. Instead, tumor purity decreased over time and was accompanied by co-increases in neuron and oligodendrocyte marker genes and, independently, tumor-associated macrophages.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified a population of granulocyte-macrophage colony-stimulating factor–producing (GM-CSF) T cells that accumulated in the kidneys of patients with antineutrophil cytoplasmic antibody–associated glomerulonephritis.
[Science Translational Medicine] |
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| Investigators determined the role of REV-ERBα in fibrogenesis induced by bleomycin and Influenza A virus. Bleomycin exposure decreases the abundance of REV-ERBα, and mice dosed with bleomycin at night display exacerbated lung fibrogenesis.
[Nature Communications] |
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| The authors reported an integrated engineering system to generate vessel-supported tumors for preclinical drug screening. Gelatin-methacryloyl hydrogel was selected to mimic tumor ECM.
[ACS Applied Materials & Interfaces] |
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| To study the interaction of invadopodia with focal adhesion and how invadopodia turn-over is associated with invasion-migration transition cycles, researchers investigated the role of Pyk2, cortactin, and Tks5 in invadopodia turnover and their relation with focal adhesions.
[Cell Death & Disease] |
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| Researchers studied the effect of exosomes derived from kartogenin-preconditioned human bone marrow mesenchymal stem cells on tendon-to-bone healing in a rat model of chronic rotator cuff tear..
[American Journal of Sports Medicine] |
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| Investigators established a simple method to simultaneously assess the molecular weight of hyaluronan in multiple crude biological samples.
[Glycobiology] |
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| The authors described two female probands from unrelated families presenting with features of a congenital connective tissue disorder including osteopenia, blue sclera, soft skin, joint hypermobility, and neuromuscular junction dysfunction.
[Human Molecular Genetics] |
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| Investigators found that Cdc37 expression was upregulated in human rheumatoid synovia in contrast with the normal group. Cdc37 activated the ERK pathway to promote RA-FLS proliferation and migration in vitro.
[Inflammation] |
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| The MXene-incorporated gelatin methacryloyl and hyaluronic acid methacryloyl bioinks were prepared to explore if they have the potential to enable the spontaneous osteodifferentiation of hMSCs when the hMSCs-laden GelMA/HAMA-MXene bioinks were 3D printed.
[Heliyon] |
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| Researchers found that the homogeneously synthesized hydroxybutyl chitosan had an effective performance in promoting wound healing.
[ACS Applied Bio Materials] |
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| Scientists produced a bilayer structure by gelling GeIMA in between two nanofiber membranes to imitate the epidermal and dermal layers of skin. Cytocompatibility properties of nanofiber membrane and bilayer structure were characterized by mono- and coculture of keratinocytes and fibroblasts, respectively.
[Journal Of Biomaterials Applications] |
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| Investigators review the importance of the tumor microenvironemnt in each stage of cancer progression, from tumor initiation, progression, invasion, and intravasation to metastatic dissemination and outgrowth.
[Cancer Cell] |
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| The authors provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic compartment.
[Bone Research] |
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| Scientists synthesize current understanding of the contribution of ECM to each stage of high-grade serous ovarian cancer development and progression, beginning at serous tubal intraepithelial carcinoma precursor lesions.
[Matrix Biology] |
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| CUTISS AG announced the start of an advanced research and development mission on board the International Space Station, leveraging the state-of-the-art micro-lab technology developed and provided by the Swiss spacetech company SpacePharma.
[Cutiss AG] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | Columbia University – New York, New York, United States/p> |
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| | Amsterdam UMC – Amsterdam, Netherlands |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | The University of Manchester – Mandarin, England, United Kingdom |
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| | Penn Medicine – Philadelphia, Pennsylvania, United States |
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