Extracellular Matrix News Volume 14.11 | Mar 23, 2023

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    2023-03-23 | ECM 14.11


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.11 – 23 March, 2023
    TOP STORY

    Immunization against Zika by Entrapping Live Virus in a Subcutaneous Self-Adjuvanting Hydrogel

    The authors showed that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provided mice with effective protection against a lethal viral challenge.
    [Nature Biomedical Engineering]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    Additive Manufacturing of Engineered Living Materials with Bio-Augmented Mechanical Properties and Resistance to Degradation

    Aqueous resins are developed comprising bovine serum albumin and poly(ethylene glycol diacrylate) with engineered microbes for vat photopolymerization to create objects with a wide array of 3D form factors.
    [Advanced Functional Materials]

    Full Article

    Infected Diabetic Wound Regeneration Using Peptide-Modified Chiral Dressing to Target Revascularization

    Scientists designed chiral gel dressing was fabricated (named as HA-LM2-RMR), which consisted of l-phenylalanine and cationic hexapeptide coassembled helical nanofibers cross-linked with hyaluronic acid via hydrogen bonding.
    [ACS Nano]

    Abstract

    Thyroid-Friendly Soft Materials as 3D Cell Culture Tool for Stimulating Thyroid Cell Function

    Using state-of-the-art characterization methods coupled with cell-based analysis and quadrupole time-of-flight mass spectrometry, it was shown that thyroid-friendly soft-microsphere-integrated thyroid cell aggregates exhibited improved thyroid function.
    [Small]

    Full Article

    Development of a ZIF-91-Porous-Liquid-Based Composite Hydrogel Dressing System for Diabetic Wound Healing

    The acrylate group on the grafted side chain of ZIF-91 porous liquid made it feasible to crosslink with modified gelatin through light curing, and the obtained hydrogel shows a significantly improved healing effect on the wound of diabetes.
    [Small]

    AbstractGraphical Abstract

    Wnt/β-Catenin Signaling Induces Axial Elasticity Patterns of Hydra Extracellular Matrix

    Researchers reported that Wnt/β-catenin signaling induced the ECM remodeling during Hydra axis formation. They determined the micro- and nanoscopic arrangement of fibrillar type I collagen along Hydra’s body axis using high-resolution microscopy and X-ray scattering.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Collagen Constitutes about 12% in Females and 17% in Males of the Total Protein in Mice

    Investigators measured hydroxyproline levels as a proxy for collagen content together with total protein levels of entire mice or of individual tissues.
    [Scientific Reports]

    Full Article

    Mechanism of YAP1 in the Senescence and Degeneration of Endplate Chondrocytes Induced by Intermittent Cyclic Mechanical Tension

    According to the Pfirrmann grade evaluation classification, 30 human endplate cartilage tissues were divided into the lumbar vertebra fracture group and lumbar disc herniation group.
    [Journal Of Orthopaedic Surgery And Research]

    Full Article

    1H–13C Cross – Polarization Kinetics to Probe Hydration – Dependent Organic Components of Bone ECM

    Scientists employed the variable contact time cross-polarization (1H – 13C CP) kinetics experiments to study the hydration–dependent atomic – level structural changes in the bone ECM.
    [Magnetic Resonance in Chemistry]

    Abstract
    Guide to everything you need to know about cell separation.
    REVIEWS

    Hydrogels for RNA Delivery

    The authors provide a comprehensive overview of hydrogel loading of RNAs and hydrogel design for controlled release, highlight their biomedical applications and offers their perspectives on the opportunities and challenges in this exciting field of RNA delivery.
    [Nature Materials]

    Full Article

    10 Years of Extracellular Matrix Proteomics: Accomplishments, Challenges, and Future Perspectives

    ECM proteins are characterized by unique biochemical properties that have hindered their study: they are large, heavily and uniquely post-translationally modified, and highly insoluble.
    [Molecular & Cellular Proteomics]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BioNTech and OncoC4 Announce Strategic Collaboration to Co-Develop and Commercialize Novel Checkpoint Antibody in Multiple Solid Tumor Indications

    BioNTech SE and OncoC4, Inc. announced that they have entered into an exclusive worldwide license and collaboration agreement to develop and commercialize OncoC4’s next-generation anti-CTLA-4 monoclonal antibody candidate, ONC-392, as monotherapy or combination therapy in various cancer indications.
    [BioNTech]

    Press Release

    Aurion Biotech Receives Approval From Japan’s PMDA For New Drug Application

    Aurion Biotech announced it has received regulatory approval from Japan’s Pharmaceuticals and Medical Devices Agency, for its novel cell therapy, VyznovaTM for the treatment of bullous keratopathy of the cornea.
    [Aurion Biotech]

    Press Release
    FEATURED EVENT

    3D Cell Culture UK

    April 25 – 26, 2023
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Developmental & Synthetic Biology

    Ariel University – Ariel, West Bank

    Laboratory Manager – Biomedical Engineering

    Columbia University – New York, New York, United States

    PhD – ECM in Cancer Development

    Amsterdam UMC – Amsterdam, Netherlands

    Postdoctoral Research Assistant – Regulating Senescence

    Queen Mary University of London – London, England, United Kingdom

    Lecturer – Cell Matrix Research

    The University of Manchester – Manchester, England, United Kingdom

    > See All Jobs

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