 | | Vol. 14.12 – 30 March, 2023 |
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| The authors reported an improved CpG-based immunotherapy approach composed of a synthetic ECM-anchored DNA/peptide hybrid nanoagonist via a tailor designed DNA template that encodes tetramer CpG and additional short DNA moieties.
[ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists discovered a collective mode of cell migration in rotating spherical tissues manifesting as a propagating single-wavelength velocity wave. This wave was accompanied by an apparently incompressible supracellular flow pattern featuring topological defects as dictated by the spherical topology.
[Nature Communications] |
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| A magnetic ink based on ultra-small iron oxide nanoparticles was developed and integrated into biocompatible alginate hydrogel used in cell scaffolding applications.
[Small] |
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| Investigators reported a moisture-adaptive fiber that rapidly absorbed wound tissue fluid and produced a large lengthwise contractile force during the drying process.
[Small] |
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| An acellular dermal matrix-based bioelectronic skin was used to fabricate versatile “wound therapy-health monitoring” tissue-nanoengineered skin scaffolds via a facile “one-pot” bio-compositing strategy.
[Advanced Healthcare Materials] |
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| Researchers showed that in mutants lacking furrows, the normal intimate connection between the epidermis and the cuticle is lost, specifically at the lateral epidermis, where, in contrast to the dorsal and ventral epidermis, there are no hemidesmosomes.
[eLife] |
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| Investigators introduced a single-step strategy toward cell-adhesive polymer networks where thiol-ene chemistry served a dual purpose. Alkene-functionalized PCL was crosslinked by means of a multifunctional thiol.
[Biomacromolecules] |
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| The authors analyzed the effects of three ECM proteins on Schwann cells in the nerve regeneration environment, including their adhesion, proliferation, and migration.
[Frontiers In Bioengineering And Biotechnology] |
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| Scientists showed that human mammary adipocytes (M-Ads) died within two–three days by necrosis when grown in 2D. As an alternative, M-Ads were grown in a fibrin matrix, a 3D model that preserved their distribution, integrity, and metabolic function for up to five days at physiological glucose concentrations.
[Scientific Reports] |
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| Some selected formulations were proceeded with rheology, pore size, chemical analysis and in vitro cellular activity of Wharton’s Jelly Mesenchymal Stem Cells, to determine the safety application of the selected hydrogels, for future cell delivery prospect.
[Scientific Reports] |
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| Researchers immersed mouse brains in oil for polymerization and decellularization via Oil-based Clinically and Experimentally Applicable Acellular Tissue Scaffold Production for Tissue Engineering and Regenerative Medicine (O-CASPER).
[Heliyon] |
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| Investigators successfully fabricated polycaprolactone salt-leached scaffolds with two levels of a biomimetic calcium phosphate coating to examine their effects on mesenchymal stem cell osteogenesis.
[Cells Tissues Organs] |
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| The authors reported on the emerging methods and cutting-edge technologies in 3D cell culture platforms and discuss their potential use in unveiling tumour microenvironmental cues, drug screening, and personalized treatment.
[FEBS Journal] |
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| The US FDA has approved Cullinan Oncology, Inc.’s Investigational New Drug application for CLN-617, a fusion protein comprised of two potent and synergistic antitumor cytokines, IL-2 and IL-12, with a collagen binding domain designed for retention in the tumor microenvironment following intratumoral injection.
[Cullinan Oncology, Inc] |
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| The American Institute for Medical and Biological Engineering has awarded its highest honor to Dr. Christine Schmidt, Professor, J. Crayton Pruitt Family Chair & Department Chair in the J. Crayton Pruitt Family Department of Biomedical Engineering.
[University of Florida] |
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| | National Institutes of Health – Research Triangle Park, North Carolina, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Monash University – Melbourne, Australia |
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| | InVitro Cell Research, LLC – Fort Lee, New Jersey, United States |
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