Extracellular Matrix News Volume 14.13 | Apr 6 2023

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    2023-04-06 | ECM 14.13


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.13 – 6 April, 2023
    TOP STORY

    An All-in-One “4A Hydrogel”: through First-Aid Hemostatic, Antibacterial, Antioxidant, and Angiogenic to Promoting Infected Wound Healing

    Inspired by the strong adhesion of mussels and the enzyme-mimicking activity of nanometallic biomaterials, the authors developed an injectable hydrogel to overcome multiple limitations of current wound dressings.
    [Small]

    Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    How the Mechanobiology Orchestrates the Iterative and Reciprocal ECM-Cell Cross-Talk That Drives Microtissue Growth

    Using de novo–grown microtissues, scientists identified crucial actors of the mechanoregulated events, which iteratively orchestrated a sharp transition from tissue growth to maturation, requiring a myofibroblast-to-fibroblast transition.
    [Science Advances]

    Full Article

    Synthetic Fibrous Hydrogels as a Platform to Decipher Cell–Matrix Mechanical Interactions

    Investigators used a highly biomimetic synthetic fibrous hydrogel to study and tailor the bidirectional cell–matrix interactions. Using advanced microscopy-based approaches, they acquired a comprehensive picture of how cellular tractions, fiber remodeling, matrix properties, and cellular behavior interact.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    3D Printing of Extracellular Matrix-Based Multicomponent, All-Natural, Highly Elastic, and Functional Materials Towards Vascular Tissue Engineering

    Investigators reported on 3D printable and perfusable multicomponent hydrogel constructs with high elasticity, self-recovery property, excellent hydrodynamic performance, and improved bioactivity.
    [Advanced Healthcare Materials]

    Abstract

    Extrusion-Based 3D Printing of Biodegradable, Osteogenic, Paramagnetic, and Porous FeMn-Akermanite Bone Substitutes

    The authors developed inks containing Fe, 35 wt% Mn, and 20 or 30 vol% akermanite powder mixtures. 3D printing was optimized together with the debinding and sintering steps to obtain scaffolds with interconnected porosity of 69%.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    Comparison of Decellularized Human Dermal Scaffolds versus Bovine Collagen/Elastin Matrices for in vivo Engineering of Axially Vascularized Soft Tissue Flaps in Rats

    Researchers investigated the suitability of a novel human dermal scaffold to improve volume retention and tissue stability.
    [Plastic And Reconstructive Surgery]

    Abstract

    Indwelling Stents Cause Severe Inflammation and Fibrosis of the Ureter via Urothelial–Mesenchymal Transition

    Tissue from stented and contralateral ureters was analyzed histologically to evaluate tissue remodelling and classify the degree of inflammation and fibrosis, while genome, proteome and immunohistochemistry analysis was performed to assess changes at the transcriptional and translational levels.
    [Scientific Reports]

    Full Article

    Identification and Characterization of Bone/Cartilage-Associated Signatures in Common Fibrotic Skin Diseases

    Researchers investigated the common biomarkers and therapeutic targets in two major fibrotic skin diseases, namely, keloid and systemic sclerosis, by bioinformatics analysis.
    [Frontiers In Genetics]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Hydrogel-Based Growth Factor Delivery Platforms: Strategies and Recent Advances

    The authors discuss recent progress in the development of growth factor-containing hydrogels for various biomedical applications, including wound healing, brain tissue repair, cartilage and bone regeneration, and spinal cord injury repair.
    [Advanced Materials]

    Abstract

    Injectable Hydrogels in Central Nervous System: Unique and Novel Platforms for Promoting Extracellular Matrix Remodeling and Tissue Engineering

    Scientists discuss the pathophysiology of the central nervous system and the use of several kinds of injectable hydrogels for brain and spinal cord tissue engineering, paying particular emphasis to recent experimental studies.
    [Materials Today Bio]

    Full Article

    3D Bioprinting Complex Models of Cancer

    The authors discuss recent examples of such 3D-bioprinted cancer models, including those of the lungs, prostate, skin, brain, and colon. They then highlight the advantages of using 3D bioprinting compared to other in vitro modeling techniques and detail its limitations.
    [Biomaterials Science]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    PathAI Announces PathExplore, an AI-Powered Pathology Panel to Unlock Untapped Insights from the Tumor Microenvironment

    PathAI the world’s first structured, standardized and scalable panel of human interpretable features offering unprecedented resolution of the tumor microenvironment from H&E whole-slide images.
    [PathAI (PR Newswire, Inc.)]

    Press Release

    Hackensack Meridian Health Awarded Nearly $477,000 for Medical Research and Community Health Projects

    Hackensack Meridian Health has been awarded 16 grants totaling nearly $477,000 from the New Jersey Health Foundation for important research and community health projects.
    [Hackensack Meridian Health]

    Press Release
    FEATURED EVENT

    The Resistant Tumor Microenvironment

    May 7 – 10, 2023
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Discovery & Translational Pharmacology

    Novartis – Cambridge, Massachusetts, United States

    Research Fellow – ECM Remodeling

    University of Surrey – Guildford, England, United Kingdom

    Postdoctoral Fellowship – Matrix Biology

    National Institutes of Health – Research Triangle Park, North Carolina, United States

    Research Scientist – Discovery & Translational Pharmacology

    Novartis – Cambridge, Massachusetts, United States

    Postdoctoral Fellowship – Computational Biology & Spatial Omics

    Harvard Medical School – Boston, Massachusetts, United States

    > See All Jobs

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