Extracellular Matrix News Volume 14.19 | May 18 2023

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    Noshin Noorjahan
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    2023-05-18 | ECM 14.19


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.19 – 18 May, 2023
    TOP STORY

    Extracellular Vesicles in Fatty Liver Promote a Metastatic Tumor Microenvironment
    The authors demonstrated that hepatocyte-derived extracellular vesicles in fatty liver enhanced the progression of colorectal cancer liver metastasis by promoting oncogenic Yes-associated protein signaling and an immunosuppressive microenvironment.
    [Cell Metabolism]
    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Germline Modifiers of the Tumor Immune Microenvironment Implicate Drivers of Cancer Risk and Immunotherapy Response
    Investigators studied 1084 eQTLs affecting the tumor immune microenvironment (TIME) found through analysis of The Cancer Genome Atlas and literature curation. These TIME eQTLs were enriched in areas of active transcription, and associated with gene expression in specific immune cell subsets.
    [Nature Communications]
    Full Article

    Phase-Separation Facilitated One-Step Fabrication of Multiscale Heterogeneous Two-Aqueous-Phase Gel
    The authors presented a one-step fabrication method based on aqueous phase separation to construct two-aqueous-phase gels that comprised multiple phases with distinct physicochemical properties.
    [Nature Communications]
    Full Article

    Rectifying Disorder of Extracellular Matrix to Suppress Urethral Stricture by Protein Nanofilm-Controlled Drug Delivery from Urinary Catheter
    To target the pathological state of the ECM, researchers designed a protein-based nanofilm-controlled drug delivery system and assembled it on the catheter.
    [Nature Communications]
    Full Article

    Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells
    The authors found that ECM-detached cells were remarkably resistant to the induction of ferroptosis. While alterations in membrane lipid content were observed during ECM-detachment, it was instead fundamental changes in iron metabolism that underlie resistance of ECM-detached cells to ferroptosis.
    [iScience]
    AbstractFull Article

    A Versatile Method to Create Perfusable, Capillary-Scale Channels in Cell-Laden Hydrogels Using Melt Electrowriting
    A novel method was demonstrated where polycaprolactone fibers printed using melt-electrowriting were encapsulated in cell-laden hydrogels and then physically removed to produce hollow, perfusable channels.
    [Macromolecular Materials And Engineering]
    Full Article

    Hybrid Cellular Potts and Bead-Spring Modelling of Cells in Fibrous Extracellular Matrix
    Scientists modeled a contractile cell pulling with discrete focal adhesion-like sites on the fiber network, and demonstrated agreement with experimental spatiotemporal fiber densification and displacement.
    [Biophysical Journal]
    Abstract

    Catch Bonds in Sickle Cell Disease: Shear-Enhanced Adhesion of Red Blood Cells to Laminin
    Researchers investigated the dynamics of sickle red blood cells adhering to a surface functionalized with the protein laminin under physiologically relevant micro-scale flow.
    [Biophysical Journal]
    Abstract

    Spatially Resolving Size Effects on Diffusivity in Nanoporous Extracellular Matrix-Like Materials with Fluorescence Correlation Spectroscopy Super-Resolution Optical Fluctuation Imaging
    Investigators showed that fluorescence correlation spectroscopy super-resolution optical fluctuation imaging could be used to accurately measure the diffusion dynamics of molecules within varying matrices such as nanopatterned surfaces and porous agarose hydrogels.
    [Journal Of Physical Chemistry B]
    AbstractGraphical Abstract
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    REVIEWS

    Pulmonary Vascular Fibrosis in Pulmonary Hypertension – The Role of the Extracellular Matrix as a Therapeutic Target
    The complexity of the regulation of vascular fibrosis and stiffening in pulmonary hypertension allows the exploration of numerous potential therapeutic interventions.
    [Pharmacology & Therapeutics]
    Abstract
    INDUSTRY AND POLICY NEWS

    OncoResponse Awarded $13 Million in Funding from CPRIT and Raises $14 Million in Added Funds from Investors to Advance Cancer Immunotherapy
    OncoResponse announced it has been awarded a $13 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT). The CPRIT award and investment will support the advancement of OR502, an anti-LILRB2 antibody poised to move to investigational new drug and clinical studies.
    [OncoResponse]
    Press Release
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    JOB OPPORTUNITIES

    Group Leader – Cancer Immunology
    VIB – Leuven, Belgium

    Junior Lab Technician – Cancer Research
    VIB – Leuven, Belgium

    PhD Position – Tumor Tissue Engineering
    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Fellow – Tumor Microenvironment
    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Research Fellow – Cellular Highways of the ECM
    National University of Singapore – Singapore, Singapore

    > See All Jobs

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