Extracellular Matrix News Volume 14.26 | Jun 8 2023

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    2023-06-08 | ECM 14.27


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.26 – 8 June, 2023
    TOP STORY

    On-Demand Heart Valve Manufacturing Using Focused Rotary Jet Spinning

    Combining rotary jet spinning and a focused air stream, focused rotary jet spinning printed FibraValves, micro- and nanofibrous heart valves, in minutes.
    [Matter]

    Full ArticlePress ReleaseGraphical Abstract
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
    PUBLICATIONSRanked by the impact factor of the journal

    Flexible Bioactive Glass Nanofiber-Based Self-Expanding Cryogels with Superelasticity and Bioadhesion Enabling Hemostasis and Wound Healing

    The authors reported a superelastic cellular-structured bioactive glass nanofibrous cryogel (BGNC) composed of highly flexible BG nanofibers and citric acid-cross-linked poly(vinyl alcohol).
    [ACS Nano]

    AbstractGraphical Abstract

    Dual Human iPSC-Derived Cardiac Lineage Cell-Seeding Extracellular Matrix Patches Promote Regeneration and Long-Term Repair of Infarcted Hearts

    Scientists demonstrated the efficacy and mechanisms of mono- and dual-human pluripotent stem cell-derived cardiovascular progenitor cells- and cardiomyocytes-seeding small intestinal submucosal extracellular matrix for repair of infarcted hearts based on the side-by-side comparison.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Engineered Extracellular Matrices Facilitate Brain Organoids from Human Pluripotent Stem Cells

    Investigators generated brain organoids using engineered extracellular matrix comprised of human fibrillar fibronectin supported by a highly porous polymer scaffold.
    [Annals Of Clinical And Translational Neurology]

    Full Article

    Effects of Anoxic Prognostic Model on Immune Microenvironment in Pancreatic Cancer

    The authors identified PLAU, LDHA, and PKM as key genes involved in pancreatic cancer hypoxia through GO/KEGG enrichment-related hypoxia pathways and cox regression, established prognostic models, and studied their relationship to immune invasion through bioinformatics using R and related online databases.
    [Scientific Reports]

    Full Article

    Contribution of Elastic and Collagen Fibers to the Mechanical Behavior of Bovine Nuchal Ligament

    Investigators combined imaging, mechanical testing, and constitutive modeling to examine the structural organization of elastic and collagen fibers and their contributions to the nonlinear stress–strain behavior of Ligamentum nuchae tissue.
    [Annals Of Biomedical Engineering]

    Abstract

    Facile Synthesis of Zinc Acetate/Niacin MOFs for Use in Wound Healing

    Release of the active ingredients from the metal-organic frameworks (MOFs) was proved to be pH dependent in a slightly alkaline medium with a sustained release rate of its two ingredients, NA and Zn, which have wound healing activity.
    [Biomedical Materials]

    Abstract

    A Unification of Nanotopography and Extracellular Matrix in Electrospun Scaffolds for Bioengineered Hepatic Models

    Scientists investigated the separate employment of topographic or biological cues on a scaffold and developed a new procedure to directly blend whole-organ vascular perfusion-decellularized rat liver ECM into electrospun fibers with tailored surface nanotopography.
    [ACS Applied Bio Materials]

    Full ArticleGraphical Abstract

    Cerebellar Axonopathy in Shivers Horses Identified by Spatial Transcriptomic and Proteomic Analyses

    Using spatial transcriptomics, gene expression was compared between Shivers and control horses in Purkinje cell soma and lateral cerebellar hemisphere white matter, consisting primarily of axons.
    [Journal Of Veterinary Internal Medicine]

    Full Article
    A person presenting slides at a scientific conference
    REVIEWS

    Epigenetic Regulation and Therapeutic Targets in the Tumor Microenvironment

    The authors focus on the mechanisms of epigenetic modifications occurring to the pivotal tumor microenvironment components including the stroma, immune and myeloid cells in various tumors reported in the last five years.

    Full Article
    INDUSTRY AND POLICY NEWS

    Regenerative Medicine Center Goes Out of This World to Explore Human Organ Research

    When the Axiom Space Ax-2 mission launched on May 21, 2023, on board were liver and kidney tissue constructs developed by the Wake Forest Institute for Regenerative Medicine. Researchers at the institute wanted to see how well the constructs vascularize, or develop blood vessels, in a microgravity environment.
    [WRAL TechWire]

    Press Release
    FEATURED EVENT

    Molecular Analysis for Precision Oncology Congress 2023

    October 4 – 6, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Postdoctoral Researchers – Molecular & Biophysical Aspects of Skin and Mucosa Barriers

    Malm̦ University РMalm̦, Sweden

    Research Assistant Professor – Obstetrics and Gynecology

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Research Associate – Extracellular Vimentin

    University of Toronto – Toronto, Ontario, Canada

    Postdoc Position – Disordered Proteins and Extracellular Proteoglycans

    University of Copenhagen – Copenhagen, Denmark

    PhD Student – Early Detection of Liver Cancer

    Helmholtz Association of German Research Centres – Heidelberg, Germany

    > See All Jobs

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