 | | Vol. 14.27 – 15 June, 2023 |
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| A galactan-enriched nanocomposite was developed from native carbohydrate structures through an optimized enzymatic transformation for effective, stable, and biosafe innate immunomodulation.
[ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occurred within the supraspinous layer of the psoriatic epidermis.
[Nature Communications] |
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| A core-shell structured microneedle array patch with programmed functions was designed to dynamically modulate the wound immune microenvironment according to the varied healing phases.
[Nature Communications] |
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| Scientists utilized both RNA interference and lipid–polymer nanoparticles to engineer a potential multiple myeloma therapy, which targeted cyclophilin A within blood vessels of the bone marrow.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| In vitro, the microfragmented adipose ECM composite demonstrated biocompatibility, printability, and fidelity and could support cell adhesion. In a full-thickness skin defect model in nude mice, cells encapsulated in the implant survived and participated in wound repair after implantation.
[ACS Applied Materials & Interfaces] |
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| Researchers showed that a time course of high-fat diet feeding progressively impaired diet-induced thermogenesis concomitantly with the development of fibro-inflammation in brown adipose tissue.
[Cell Reports] |
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| Adult stem/progenitor cells were isolated from human adipose, bone marrow, and articular cartilage, and cultured for 14 days in monolayer in mesenchymal stromal cell–ECM induction medium to allow matrix deposition and cell sheet formation.
[Stem Cell Research & Therapy] |
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| The ECM was obtained from caprine bone by a combination of demineralization, delipidation and decellularization (D3) techniques. The bone D3-derived ECM tissue was characterized for analyzing the effective removal of cells, minerals, and lipids with an intact structure and chemical composition.
[Biomaterials Science] |
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| Acellular melt electrowriting (MEW)-norbornene-modified hyaluronic acid (NorHA) composites or MEW-NorHA composites with encapsulated porcine MSCs and precultured for 28 days were implanted in full-thickness cartilage defects in porcine knees.
[International Journal Of Bioprinting] |
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| Investigators highlight recent development and use of engineered natural hydrogel platforms that mimic the ECM and present defined biochemical and mechanical cues for vascularization.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| The authors explore the ECM changes, cellular effectors, and the mechanisms of ECM remodeling throughout PMN progression, as well as its impact on shaping the pre-metastatic niche and ultimately promoting metastasis.
[Frontiers In Oncology] |
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| SCTbio and Cyto-care.eu GmbH, a company that specializes in providing advanced solutions for cell therapy and regenerative medicine, have signed a collaboration agreement to improve the quality of cryopreservation for cell therapy development in Europe.
[CTBio] |
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| August 25 – 28, 2023
Amsterdam, Netherlands & Virtual |
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| | LAAS-CNRS – Toulouse, France |
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| | TU Dresden – Dresden, Germany |
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| | Sorbonne-Universite – Paris, France |
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| | Malm̦ University РMalm̦, Sweden |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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