 | | Vol. 14.28 – 21 June, 2023 |
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| Investigators demonstrated in mice that the ability to reopen the social reward learning critical period was a shared property across psychedelic drugs. The time course of critical period reopening was proportional to the duration of acute subjective effects reported in humans.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By introducing chain entanglements into the hydrogel network made of folded elastomeric proteins, researchers were able to engineer highly stiff and tough protein hydrogels, which seamlessly combined mutually incompatible mechanical properties.
[Nature] |
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| Investigators demonstrated that depsipeptides could undergo enzyme-triggered changes in their primary sequence, with proof-of-principle studies showing how trypsin-triggered primary sequence rearrangement forms the bioadhesive pentapeptide YIGSR.
[Nature Communications] |
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| Researchers examined the role of argininosuccinate synthetase 1 silencing on tumor growth and initiation and identified a noncanonical mechanism of resistance, aiming to improve clinical responses to ADI-PEG20.
[Clinical Cancer Research] |
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| Adhesion to the ECM proteins collagen IV and laminin-1 increased the number of Ca2+ microdomains in a manner dependent on the kinase FAK, phospholipase C, and all three inositol 1,4,5-trisphosphate receptor subtypes and promoted the nuclear translocation of the transcription factor NFAT-1.
[Science Signaling] |
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| Scientists identified and localized age‑associated ECM differences in human lung using comprehensive transcriptomic, proteomic and immunohistochemical analyses.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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Researchers provide independent replication of foundational in vivo diabetic wound closure studies, observing 16% faster healing under treatment with observable microscopic benefits.
[Scientific Reports] |
| | The authors identified a prognostic signature of pyroptosis-related genes (PRGs) and explored the connection of PRGs with the tumor microenvironment in lung adenocarcinoma. Gene expression and clinical information were obtained from The Cancer Genome Atlas database.
[Scientific Reports] |
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| Scientists exposed dermal fibroblasts to a set of altered gravity levels, including transitions between simulated microgravity and hypergravity. The addition of the stress hormone cortisol to the cell culture medium was done to account for possible interaction effects of gravity and cortisol exposure.
[NPJ Microgravity] |
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| Researchers presented a muscular organoid produced from the bovine diaphragm, which had a peculiar multilayered structure with different fiber orientations depending on the considered area.
[Journal Of Anatomy] |
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| The pleiotropic effect of cancer-associated fibroblasts in the tumor microenvironment is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| The authors provide an overview of the glioma microenvironment, describe novel approaches for clustering patients based on their tumor immune profile, and discuss the latest progress on utilization of radiomics for immune profiling of glioma based on current literature.
[NPJ Precision Oncology] |
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| Nordic Bioscience announced that the company’s PRO-C3 biomarker assay has received a Letter of Support from the FDA. This letter acknowledges and supports further study of the PRO-C3 biomarker assay as a prognostic biomarker in tumor fibrosis studies.
[Nordic Bioscience,] |
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| For nearly four years, a Massachusetts Institute of Technology (MIT) bioengineering professor remained silent while an inquiry unfolded into allegations that his research copied the work of others. That investigation has concluded, finding no basis that Ram Sasisekharan or the members of his lab engaged in research misconduct.
[MedCity News] |
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| Dr. McGarry Houghton, a pulmonary physician-scientist whose work explores the immune system’s role in cancer and lung cancer early detection, has been named the first recipient of the Satya and Rao Remala Family Endowed Chair at Fred Hutchinson Cancer Center.
[Fred Hutch Cancer Center] |
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| July 18 – 20, 2023
Boston, Massachusetts, United States |
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| | King’s College London – London, England, United Kingdom |
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| | University College Dublin – Dublin, Leinster, Ireland |
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| | University of Colorado Boulder – Boulder, Colorado, United States |
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| | TU Dresden – Dresden, Germany |
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| | LAAS-CNRS – Toulouse, France |
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