 | | Vol. 14.29 – 29 June, 2023 |
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| Researchers showed that functionally distinct T cell populations can be generated from T cells that received the same stimulation by altering the viscoelasticity of their surrounding ECM.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a multiplexed biophysical imaging approach for single-cell analysis of human cell lines, wthe authors showed how the subprocesses of adhesion, contractility, actin cytoskeletal dynamics, and matrix remodeling integrate to produce heterogeneous migration behaviors.
[Developmental Cell] |
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| Conductive biohybrid platforms were engineered by blending collagen type I and 2D MXene (Ti3C2Tx) and afterwards covalently crosslinking; to harness the biofunctionality of the protein component and the increased stiffness and enhanced electrical conductivity that 2Dl titanium carbide provides.
[NPJ 2D Materials And Applications] |
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| Investigators showed that Collagen VI (Col VI) deposition correlated with stromal T cell density in human prostate cancer specimens. Motility of CD4+ T cells was completely ablated on purified Col VI surfaces when compared with Fibronectin and Collagen I.
[Matrix Biology] |
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| The authors used the migration of the border cells of the Drosophila egg chamber to unravel a new role of encasing basement membrances in cell migration.
[PLOS Biology] |
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| Researchers identified a role for Drosophila Perlecan in the maintenance of larval motoneuron axonal and synaptic stability. Loss of Perlecan caused alterations in the axonal cytoskeleton, followed by axonal breakage and synaptic retraction of neuromuscular junctions.
[eLife] |
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| To separate glucose effects from lipid effects on adipose tissue, researchers used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet.
[iScience] |
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| Using tissue from non-small cell lung cancer patients undergoing curative intent surgery, the authors characterized quantitative tumor-specific ECM proteome signatures by mass spectrometry.
[Frontiers In Oncology] |
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| Scientists reported the development and characterization of a physiologically relevant air–liquid interface 3D airway ‘organ tissue equivalent’ model with three novel features: native pulmonary fibroblasts, solubilized lung ECM, and hydrogel substrate with tunable stiffness and porosity.
[Scientific Reports] |
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| The authors developed a method of culturing intestinal organoids within suspended basement membrane extracted hydrogels of various geometries, which streamlined the protocol, increases the scalability, enabled kinetic sampling, and improved culture uniformity without specialized equipment or additional expertise.
[Scientific Reports] |
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| A rat ovariectomy model was used to induce estrogen deficiency. The experiments indicated that ovariectomy significantly promoted osteoclastogenesis and anabolism and catabolism changes in endplate chondrocytes.
[Heliyon] |
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| The authors investigate the molecular mechanisms underlying adult degenerative scoliosis , with a focus on angiogenesis, inflammation, ECM remodeling, osteoporosis, sarcopenia, and biomechanical stress.
[Trends In Molecular Medicine] |
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| Scientists discuss the different types of senescent cells present in the tumor microenvironment (TME) and how these senescent cells and their senescence-associated secretory phenotype reshape the TME, affect immune responses, and influence cancer progression.
[Developmental Cell] |
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| Three University Hospitals and Case Western Reserve University School of Medicine research teams recently received Collaborative Science Pilot Awards. The teams each received $50,000, funded by both institutions.
[Case Western University] |
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| The interdisciplinary team of Cathal Kearney, assistant professor of biomedical engineering, and Govind Srimathveeravalli, assistant professor in mechanical and industrial engineering, has received the 2023 Armstrong Fund for Science Award.
[University of Massachusetts Amherst] |
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| August 6 – 11, 2023
South Hadley, Massachusetts, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | KU Leuven – Leuven, Belgium |
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| | King’s College London – London, England, United Kingdom |
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| | LAAS-CNRS – Toulouse, France |
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