Extracellular Matrix News Volume 14.30 | Jul 6 2023

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    2023-07-06 | ECM 14.30


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.30 – 6 July, 2023
    TOP STORY

    Macrophage-Mediated Extracellular Matrix Remodeling Controls Host Staphylococcus aureus Susceptibility in the Skin

    Hypodermal macrophages (HDMs) homeostasis required the fibroblast-derived growth factor CSF1, ablation of which abrogated HDMs from the hypodermal adventitia.
    [Immunity]

    AbstractGraphical Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload

    Researchers characterized cardiac physiology and used single-cell RNA-sequencing and in vitro studies to investigate the p53-dependent mechanisms regulating cardiac fibroblast cell cycle and fibrosis in left ventricular pressure overload induced by transaortic constriction.
    [Circulation Research]

    AbstractPress Release

    A Localized Hydrogel-Mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-Mediated Unfolded Protein Response

    The authors presented a hydrogel-mediated localized delivery of a combination of docetaxel and carboplatin that ensured enhanced anticancer effect and tumor regression on multiple murine syngeneic and xenograft tumor models.
    [Science Advances]

    Full Article

    Reciprocal Discoidin Domain Receptor Signaling Strengthens Integrin Adhesion to Connect Adjacent Tissues

    Scientists investigated how cells achieve synchronized adhesion to connect tissues using the Caenorhabditis elegans utse-seam tissue connection that supports the uterus during egg-laying.
    [eLife]

    Full Article

    Multiscale Model of the Different Modes of Cancer Cell Invasion

    Researchers presented a model of tumor cell invasion simulated with PhysiBoSS, a multiscale framework, which combines agent-based modeling and continuous time Markov processes applied on Boolean network models.
    [Bioinformatics]

    Full Article

    Sea Stars Resist Wasting Through Active Immune and Collagen Systems

    The authors measured gene expression longitudinally of 24 adult Pisaster ochraceus sea stars, collected from a recovered site, as they remained asymptomatic or naturally progressed through sea star wasting in individual aquaria.
    [Proceedings Of The Royal Society B-Biological Sciences]

    Full Article

    Efficacy of a Collagen Matrix for Soft Tissue Augmentation After Implant Placement Compared to Connective Tissue Grafts: A Multicenter, Noninferiority, Randomized Controlled Trial

    Subjects in need of soft tissue volume augmentation at single tooth implant sites were consecutively recruited at nine centers.
    [Clinical Oral Implants Research]

    Full Article

    Loss of Collagen Gene Expression in the Notochord of the Tailless Tunicate Molgula occulta

    Using CRISPR/Cas9-mediated mutagenesis in the tailed laboratory model tunicate Ciona robusta, the authors demonstrated that Col1/2a played a crucial role in the convergent extension of notochord cells during tail elongation.
    [Integrative And Comparative Biology]

    Abstract

    Improvement of Wound Healing by Capsaicin through Suppression of the Inflammatory Response and Amelioration of the Repair Process

    Researchers analyzed the effects of capsaicin on wound healing using an in vitro cell model and an in vivo animal model. Cell migration, viability and inflammation were examined using fibroblasts, and wounds were evaluated in mice under CAP treatment.
    [Molecular Medicine Reports]

    Abstract
    Explore virtual support and resources to stay productive and connected with your field.
    REVIEWS

    Collagen Architecture and Signaling Orchestrate Cancer Development

    Scientists focus on macropinocytosis-dependent collagen support of cancer cell metabolism and the role of collagen fiber remodeling and trimer heterogeneity in control of tumor bioenergetics, growth, progression, and response to therapy.
    [Trends In Cancer]

    Abstract

    TNF Superfamily Control of Tissue Remodeling and Fibrosis

    The authors summarize select tumor necrosis super family and their involvement in fibrosis of the lungs, the heart, the skin, the gastrointestinal tract, the kidney, and the liver.
    [Frontiers In Immunology]

    Full Article

    miRNAs as Key Modulators Between Normal Cells and Tumor Microenvironment Interactions

    Scientists summarize various roles of miRNAs in the complex interactions between the tumor and normal cells in their microenvironment.
    [Chemical Biology & Drug Design]

    Abstract
    INDUSTRY AND POLICY NEWS

    Vanderbilt Researchers Envision the Potential to Grow New Lungs

    To continue their work and to determine the molecular and cellular basis for a lung disease of prematurity called bronchopulmonary dysplasia, Dr. Jennifer Sucre and her colleagues have been awarded a five-year, $3.5-million grant by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
    [Vanderbilt University]

    Press Release

    CRI’s Sean Morrison Elected to European Molecular Biology Organization

    Stem cell biologist Dr. Sean Morrison, Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern, has been elected by his peers as an associate member of the European Molecular Biology Organization.
    [UT Southwestern Medical Center]

    Press Release
    FEATURED EVENT

    Cell Symposia: Structural Biology from the Nanoscale to Cellular Mesoscale

    November 3 – 5, 2023
    Huangshan, China

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Confinement Mechanobiology

    National University of Singapore – Singapore, Singapore

    Postdoctoral Fellow – Tumor Microenvironment

    Francis Crick Institute – London, England, United Kingdom

    Cell Manufacturing Specialist – Cell Therapy

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    PhD Position – Metabolic Alterations in Skeletal Progenitors

    KU Leuven – Leuven, Belgium

    Lecturer – Bioengineering

    King’s College London – London, England, United Kingdom

    > See All Jobs

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