 | | Vol. 14.35 – 24 August, 2023 |
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| The authors demonstrated a light-guided patterning platform that uses natural ECM-proteins as a substrate to program cellular behaviors. They utilized a photocaged diene which underwent Diels–Alder based click chemistry upon uncaging with 365 nm light.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists presented the single-cell transcriptomic landscape of synchronously resected pancreatic ductal adenocarcinoma primary tumors and matched liver metastases. They performed comparative analysis on both cellular composition and functional phenotype between primary and metastatic tumors.
[Nature Communications] |
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| Photocrosslinkable gelatin methacrylate was used as a 3D culturing hydrogel to encapsulate cells, and circulate tumor culture medium adjacent to the hydrogel to verify the critical role of mesenchymal stem cells and osteoclasts.
[Small] |
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| With two-photon time-lapse imaging of bone explant culture, researchers provided direct evidence showing that α-parvin regulates chondrocyte rotation, a process essential for chondrocytes to form columnar structure.
[Bone Research] |
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| The authors found that SAM68 was transiently localized at the edge of spreading cells where it participates in membrane protrusive activity and the conversion of nascent adhesions to mechanically loaded focal adhesions by modulation of integrin signaling and local delivery of β-actin mRNA.
[eLife] |
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| Synovium, collected from 10 patients with advanced osteoarthritis during total knee replacement surgery, was collagenase-digested, and cells were stained for flow cytometry analysis.
[Arthritis Research & Therapy] |
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| Scientists focus on the molecular properties of senescence-associated secretary phenotype and its regulatory mechanisms. Furthermore, the pathophysiological process of ECM remodeling by senescence-associated secretary phenotype factors.
[American Journal Of Physiology-Cell Physiology] |
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| The authors developed 3D bioprinted in vitro models of the breast cancer tumor microenvironment made of co-cultured cells distributed in a hydrogel matrix with controlled architecture to model tumor heterogeneity.
[Scientific Reports] |
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| Human bone marrow-derived mesenchymal stem cells were seeded on the surfaces of hydroxyapatite-based scaffolds and cultured for 21 days in three different conditions: static 3D culture, 3D culture in a perfusion bioreactor, and dynamic 3D culture in a rotating bioreactor.
[Scientific Reports] |
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| Focusing on pancreatic islets, a type 2 diabetes relevant tissue, researchers showed that their model learned islet-specific transcription factor regulatory patterns and could be used to prioritize candidate causal variants.
[Cell Death & Disease] |
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| The authors critically present and discuss specific biomechanical functions of ECMs and regulatory adaptation mechanisms in both health and disease, with a particular focus on cancer progression.
[FEBS Journal] |
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| Two national leaders in the biomedical engineering field, Michael King and Cynthia Reinhart-King, whose research programs have advanced the understanding and treatment of cancer and other diseases, will join the Rice University faculty next year.
[Rice University] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | The University of Copenhagen – Copenhagen, Denmark |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | National University Singapore – Singapore, Singapore |
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