Extracellular Matrix News Volume 14.36 | Aug 31 2023

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    2023-08-31 | ECM 14.36


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.36 – 31 August, 2023
    TOP STORY

    A 3D-Printed Assemblable Bespoke Scaffold As Versatile Microcryogel Carrier for Site-Specific Regenerative Medicine

    After characterization, scientists investigated possible site-specific applications by utilizing hive-structured assemblable bespoke scaffold as a versatile carrier with incorporated treatments such as growth factors, bioceramic, or cells.
    [Advanced Materials]

    Abstract
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    Divergent Chondro/Osteogenic Transduction Laws of Fibrocartilage Stem Cell Drive Temporomandibular Joint Osteoarthritis in Growing Mice

    Lineage tracing using Gli1-CreER+; Tmfl/- mice and Sox9-CreER+;Tmfl/- mice showed that anterior disc displacement interfered with the chondrogenic capacity of Gli1+ fibrocartilage stem cells as well as osteogenic differentiation of Sox9+ lineage, mainly in the middle zone of temporomandibular joint cartilage.
    [International Journal Of Oral Science]

    Full Article

    Serine Protease 35 Regulates the Fibroblast Matrisome in Response to Hyperosmotic Stress

    The authors used sorbitol-treated human fibroblasts in 3D culture to study the consequences of hyperosmotic stress in the skin.
    [Science Advances]

    Full Article

    Molecular Neurobiology of Loss: A Role for Basolateral Amygdala Extracellular Matrix

    A comprehensive multi-omics investigation of the basolateral amygdala, spanning multiple cohorts, platforms, and analyses, revealed alterations in microglia and the ECM.
    [Molecular Psychiatry]

    Full Article

    Development and Characterization of Biological Sutures Made of Cell-Assembled Extracellular Matrix

    In vivo carotid anastomoses realized in sheep demonstrated that the biological sutures were compatible with standard vascular surgery techniques.
    [Biofabrication]

    Full Article

    Extracellular Matrix Stiffness Regulates Microvascular Stability by Controlling Endothelial Paracrine Signaling to Determine Pericyte Fate

    Primary microvessels were cultured in the tubular microvascular growth medium on 2D stiff substrates. Stiff ECM was prepared by incubating ECM solution in regular culture dishes for one hour followed by PBS wash.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Abstract

    LZTR1 Deficiency Exerts High Metastatic Potential by Enhancing Sensitivity to EMT Induction and Controlling KLHL12-Mediated Collagen Secretion

    Scientists found that leucine zipper-like transcriptional regulator 1 (LZTR1) deficiency significantly increased lung metastasis, and promoted ECM deposition around metastatic tumors.
    [Cell Death & Disease]

    Full Article

    Testicular Germ Cell Tumor Cells Release microRNA-Containing Extracellular Vesicles That Induce Phenotypic and Genotypic Changes in Cells of the Tumour Microenvironment

    Researchers comprehensively examined the role of extracellular vesicles, and their miRNA cargo, on fibroblast, endothelial, and macrophage cells representative of the testicular germ-cell-tumor microenvironment.
    [International Journal Of Cancer]

    Full ArticleGraphical Abstract

    Knockout of All ErbB-Family Genes Delineates Their Roles in Proliferation, Survival and Migration

    Investigators knocked out each ErbB gene, various combinations of ErbB genes or all ErbB genes in Madin–Darby canine kidney cells to delineate the contribution of each gene.
    [Journal Of Cell Science]

    Abstract
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    REVIEWS

    The Extracellular Matrix in Hepatocellular Carcinoma: Mechanisms and Therapeutic Vulnerability

    The authors discuss the contributions of various ECM components that impact hepatocytes and their surrounding support network during tumorigenesis.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Polymeric and Biological Membranes for Organ-on-a-Chip Devices

    The relevance of organ-on-a-chips with membranes is discussed as well as their scaffold and actuation roles, physical and material properties, and fabrication methods in different organ models.
    [Microsystems & Nanoengineering]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    US Extends Science Pact with China: What It Means for Research

    The US government has extended for six months a key symbolic agreement to cooperate with China in science and technology.
    [Nature]

    Editorial
    FEATURED EVENT

    SIOP 2023 Congress

    October 11 – 14, 2023
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    JOB OPPORTUNITIES

    Principal Scientist – Translational Modeling & Simulation

    Novartis – United States

    Research Associate – Pulmonary Research

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Senior Scientific Officer – mRNA Translation Rates on ECM

    Beatson Institute – Glasgow, Scotland, United Kingdom

    Postdoctoral Position – Modeling of the Tumor Microenvironment

    The University of Copenhagen – Copenhagen, Denmark

    > See All Jobs

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