 | | Vol. 14.36 – 7 September, 2023 |
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| Researchers developed a composite fibrous hydrogel to vary gel stiffness without affecting structure by controlling intrafibrillar crosslinking. The hydrogel was formed from aldehyde-modified cellulose nanocrystals and gelatin methacryloyl that provided the capability of intrafibrillar photocrosslinking.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting these cell populations and their associated glioblastoma hallmarks of stemness and immunosuppression.
[Nature Immunology] |
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| The authors assessed the efficacy of Lewis Y antigen (LeY)-specific CAR T cells in patient-derived xenograft models of prostate cancer. In vitro , LeY CAR T cells directly killed organoids derived from androgen receptor (AR)-positive or AR-null PDXs.
[Nature Communications] |
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| Scientists found that the ECM protein, Dumpy, guided the position and direction of buckling-induced folds. Dumpy anchored the wing epithelium to the overlying cuticle at specific tissue positions.
[Science Advances] |
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| Cell behavior videos showed that the morphological transformation from multiple spheroidal units with morphogenesis competence to planar skin was characterized by two abrupt cell motility–increasing events before calming down.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors established a spatiotemporal “resistance-adaptive propulsion” theory based on the interactions between Arp2/3 complexes and polymerizing actin filaments and a multiscale dynamic modeling system spanning from molecular proteins to the cell.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| A bioinspired cellulose nanofibrils (CNF)/chitosan (CS) composite thread containing 5% cationic polyacrylamide by the mass of CS was prepared, and the obtained CNF/CS-5C thread exhibited excellent mechanical properties and low swelling ratio in water due to the high cross-link degree.
[ACS Applied Materials & Interfaces] |
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| Researchers compared abundances of ECM proteins from excised valve tissues of 88 patients with isolated aortic valve degeneration (AVD) of normal tricuspid and congenital bicuspid aortic valves, quantified more than 1400 proteins per ECM sample by mass spectrometry.
[Cellular And Molecular Life Sciences] |
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| A distal renal tubular system-on-a-chip was constructed to explore the pathogenesis. The renal tubule–vascular reabsorption interface was recapitulated by co-culturing the distal renal tubule and peritubular vessel with a collagen-coated porous membrane.
[Lab On A Chip] |
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| The authors discuss the contributions of various ECM components that impact hepatocytes and their surrounding support network during tumorigenesis.
[Cell Reports Medicine] |
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| Sushi, von Willebrand factor type A, epidermal growth factor, and pentraxin domain containing 1 (SVEP1) is contained within the extracellular matrix and circulates in plasma, making it a priority candidate for disease diagnostics, prognostics, and therapeutics.
[Trends In Molecular Medicine] |
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| New evidence provides a strong impetus to explore heparan sulfate as a potential novel therapeutic agent to treat periodontitis, support alveolar bone maintenance, and promote bone formation.
[Periodontology 2000] |
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| With help from NIA, biotechnology company Juvena Therapeutics has begun unlocking the secrets of proteins for regenerative medicine. Juvena scientists are using a form of muscular dystrophy — myotonic dystrophy type 1 — as a model to sift through proteins that are produced by the body’s stem cells.
[National Institute of Aging] |
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| Most scientists consider stem cells the A-side when it comes to the race to curing disease. But FibroBiologics has set its sights on fibroblasts. The most common cell in the body, fibroblasts are the main cell type in connective tissue.
[InnovationMap] |
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| October 1 – 4, 2023
Whistler, British Columbia, Canada |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
