 | | Vol. 14.37 – 13 September, 2023 |
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| The authors developed a powerful platform technology combining magneto-responsive hydrogel, cells, and wireless magneto-induced dynamic mechanical stimulation to accelerate diabetic wound healing.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated articular cartilage-like tissues from induced-(i) PSCs from two patients with progressive pseudorheumatoid arthropathy of childhood and one wild-type human embryonic stem cell line in which we knocked out WISP3.
[Annals Of The Rheumatic Diseases] |
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| The authors characterized mucus proteins, glycosylation, ion content, and mechanical properties that could be used to provide insight into structure-function relationships through an integrative “mucomics” approach.
[Nature Communications] |
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| Scientists reported that human induced pluripotent stem cell derived cardiac fibroblasts differentiated on Matrigel and expanded on tissue culture plastic exhibited transcriptomic hallmarks of activated fibroblasts limiting their translational potential.
[Bioactive Materials] |
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| Researchers cultured circulating tumor cell-like DU4475 TNBC cells in mechanically tunable 3D fibrin hydrogel scaffolds. Mechanically tunable fibrin gels revealed specific matrix-based regulation of triple negative breast cancer cell phenotype.
[Advanced Healthcare Materials] |
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| Investigators showed that a male-specific genetic switch in a single C. elegans glial cell patterns the overlying aECM from a solid sheet to an ∼200 nm pore, thus allowing a male sensory neuron to access the environment.
[Current Biology] |
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| The authors developed a granular aggregate-prevascularized (GAP) bioink for engineering highly vascularized bone tissues by capitalizing on the condensate-mimicking, self-organization, and angiogenic properties of prevascularized mesenchymal spheroids.
[ACS Applied Materials & Interfaces] |
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| Investigators developed a novel approach to produce Atomic Force Microscopy (AFM) probes that faithfully retained the structural and biochemical complexity of the ECM; this was achieved by attaching to an AFM cantilever a micrometric slice of native decellularised ECM, which was cut by laser microdissection.
[Nanoscale] |
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| Researchers showed that anti-NC16A IgEs significantly increased levels of key eosinophil chemoattractants, eotaxin-1 and eotaxin-2, as well as the proteolytic enzyme matrix metalloproteinase-9 in the lesional skin of FcεRI/NC16A mice.
[Journal Of Immunology] |
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| The expression and clinical information were obtained from The Cancer Genome Atlas database. Principal components analysis was used to discriminate between laryngeal squamous cell carcinoma and normal samples. The hub genes were screened out through univariate and multivariate cox analyses.
[Heliyon] |
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| Investigators discuss the role of SHP2 in cancer and the tumor microenvironment, and the clinical strategies in which SHP2 inhibitors are leveraged as combination agents to improve therapeutic response.
[Cancer Discovery] |
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| The Max Planck-Humboldt Medal will be awarded to Kandice Tanner from the Center for Cancer research, NCI NIH, for developing methods of analyzing the biophysical properties and behavior that dictate the metastatic spread of cancer cells.
[Max-Planck-Gesellschaft] |
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| Currently, there are only two anti-fibrotic drugs endorsed by the FDA for the treatment of pulmonary fibrosis. Neither treatment can completely stop or reverse the lung damage, highlighting the need for novel therapeutics. A recently published study in Nature Communications suggests that glycogen could be an important therapeutic target.
[The Scientist] |
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| October 19 – 22, 2023
San Diego, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | The Roger Williams Institute of Hepatology – London, England, United Kingdom |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Creative Biolabs – New York, New York, United States |
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