Extracellular Matrix News Volume 14.38 | Sep 21 2023

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    Laurisa Dohm
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    2023-09-21 | ECM 14.38


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.38 – 21 September, 2023
    TOP STORY

    Activation of the Transcription Factor NFAT5 in the Tumor Microenvironment Enforces CD8+ T Cell Exhaustion

    Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8+ T cell exhaustion.
    [Nature Immunology]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    A TGFβ-ECM-Integrin Signaling Axis Drives Structural Reconfiguration of the Bile Duct to Promote Polycystic Liver Disease

    The development of cystic tissue required the activation of transforming growth factor–β (TGFβ) signaling, which promoted the expression of a procystic, fibronectin-rich ECM and which itself was perceived by a changing profile of integrin receptors on the cystic epithelium.
    [Science Translational Medicine]

    Abstract

    A Bioengineered Trachea-Like Structure Improves Survival in a Rabbit Tracheal Defect Model

    Investigators fabricated bioengineered cartilage rings from three-dimensionally printed fibers of poly(É›-caprolactone) and rabbit chondrocytes.
    [Science Translational Medicine]

    Abstract

    Exploring Mechanical Responses of Cells to Geometric Information Using Micropatterned DNA-Based Molecular Tension Probes

    To investigate the mechanical role of integrin in the geometrical interplay between cells and the ECM, researchers proposed a single-cell micropatterning technique combined with molecular tension fluorescence microscopy.
    [ACS Nano]

    AbstractGraphical Abstract

    Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration

    The development of a novel ECM hydrogel@exosomes was reported, which entailed incorporation of adipose-derived mesenchymal stem cell-derived exosomes into an ECM hydrogel.
    [Advanced Science]

    Full Article

    Local BMP2 Hydrogel Therapy for Robust Bone Regeneration in a Porcine Model of Legg-Calvé-Perthes Disease

    Scientists developed a bone morphogenetic protein-2 (BMP2)-hydrogel treatment via a transphyseal bone wash and subsequential injection of BMP2-loaded hydrogel.
    [NPJ Regenerative Medicine]

    Full Article

    Glycoprotein Injectable Hydrogels Promote Accelerated Bone Regeneration through Angiogenesis and Innervation

    Investigators reported the role of mucin in ECM formation validated by RNA sequencing analysis of human bone marrow derived mesenchymal stem cells.
    [Advanced Healthcare Materials]

    Abstract

    Native Extracellular Matrix Probes to Target Patient- and Tissue-Specific Cell–Microenvironment Interactions by Force Spectroscopy

    The authors developed a novel approach to produce Atomic Force Microscopy (AFM) probes that faithfully retained the structural and biochemical complexity of the ECM; this was achieved by attaching to an AFM cantilever a micrometric slice of native decellularised ECM, which was cut by laser microdissection.
    [Nanoscale]

    Full ArticleGraphical Abstract

    Lysyl Oxidase-Dependent Extracellular Matrix Crosslinking Modulates Calcification in Atherosclerosis and Aortic Valve Disease

    Lysyl oxidase (LOX) conditions ECM biomechanical properties, and was upregulated in calcified valves from two cohorts of calcific aortic valve disease patients.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
    REVIEWS

    Bioinspired Multiphase Composite Gel Materials: From Controlled Micro-Phase Separation to Multiple Functionalities

    The critical design criteria and fabrication strategies of gel materials with micro-phase separation are summarized. Then, the multiple functionalities of these materials are systemically reviewed, including surface engineering, mechanical properties, shape memory, and sensor properties.
    [Chem]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    NIH Upholds Controversial Plan to Step Up Oversight of Foreign Collaborators

    The US biomedical agency tweaked its new policy after an outcry from researchers, but will forge ahead.
    [Nature News]

    Editorial
    FEATURED EVENT

    Organoids: Modelling Organ Development and Disease in 3D Culture

    October 18 – 21, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Researchers – Bioengineering and Morphogenesis

    KU Leuven – Leuven, Belgium

    Faculty and Postdoc Positions – iHuman Institute

    ShanghaiTech University – Shanghai, China

    Assistant Professor – Cancer, Cardiovascular and Metabolic Health, or Brain, Mind, and Behavior

    Northwestern University – Chicago, Illinois, United States

    Research Technician – Liver Regeneration and Tissue Engineering

    The Roger Williams Institute of Hepatology – London, England, United Kingdom

    Associate Professor – Bioengineering

    University of Maryland – College Park, Maryland, United States

    > See All Jobs

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