 | | Vol. 14.39 – 28 September, 2023 |
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| Investigators reported curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation was regulated by the membrane curvatures imposed by the topography of ECM protein fibers.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers revealed a potential mechanism by which KRT5+ cells migrate within the fibrotic lung, navigating regional differences in collagen topography. In vitro, KRT5+ cell migratory characteristics and expression of remodeling genes are modulated by extracellular matrix composition and organization.
[Nature Communications] |
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| Increased expression of TKS5, a scaffold protein essential for the formation of podosomes, was detected in the lung tissue of Idiopathic Pulmonary Fibrosis patients and bleomycin-treated mice.
[Nature Communications] |
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| By high-resolution imaging, researchers observed a direct transfer of fluorescently tagged ROR2 from cancer-associated fibroblasts to the gastric cancer cell line AGS cells by signaling filopodia, known as cytonemes.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists demonstrated that incorporating human pancreatic decellularized ECM within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Acta Biomaterialia] |
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| Vasculogenic hydrogels were embedded within a highly porous, biostable 3D polydimethylsiloxane scaffold. Using reverse-casting of 3D-printed molds, scaffolds exhibited highly interconnected and reproducible pore structures.
[Acta Biomaterialia] |
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| Inhibition of NLRP3 caused significantly reduced proliferation of intestinal fibroblasts from inflammatory bowel diseases patients, which was associated with a marked decrease in production of collagen type I and type VI.
[Journal Of Crohns & Colitis] |
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| Scientists demonstrated that the softer matrix microenvironment induces a shift in glioblastoma cell metabolism toward glycolysis, which manifested in lower proliferation rate and increased migration activities.
[Cell Reports] |
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| Investigators showed that transferring mouse dermal fibroblasts from soft to stiff substrates caused an up-regulation of arginine and proline metabolism, and that increased matrix stiffness stimulated the expression and activity of key metabolic enzymes.
[Cell Death Discovery] |
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| The authors focus on the description of existing 3D models, the incorporation of TME and fluidics into these models, and their perspective in the future research.
[Experimental Biology And Medicine] |
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| As well as the $47 million upfront payment, Orionis will be eligible for over $2 billion in milestone payments on top of royalties. Molecular glues are small molecules used to stabilize the interaction between two proteins that don’t typically interact.
[Fierce Biotech] |
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| October 20 – 24, 2023
Madrid, Spain |
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| | Institut de Biologie Paris Seine – Paris, France |
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| | KU Leuven – Leuven, Belgium |
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| | Northwestern University – Chicago, Illinois, United States |
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| | The Roger Williams Institute of Hepatology – London, England, United Kingdom |
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| | University of Maryland – College Park, Maryland, United States |
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