 | | Vol. 14.42 – 19 October, 2023 |
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| The authors demonstrated that chemical carcinogen-exposed cancer cells failed to establish an immunosuppressive tumor microenvironment, resulting in their T cell–mediated rejection in vivo.
[Journal Of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that exposure to a solubilized basement membrane matrix substrate, Matrigel, at early neuroepithelial stages caused rapid tissue polarization and rearrangement of neuroepithelial architecture.
[EMBO Journal] |
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| To address the functional coupling of ECM composition and matrix rigidity on compliant substrates, investigators developed a matrix spot array system to screen cell phenotypes against different ECM mixtures on defined substrate stiffnesses at high resolution.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Mesoporous silica was used as a model material of Si-based biomaterials. Experiments showed that the supernatant of CD4+ T lymphocytes pretreated with mesoporous silica extract significantly promoted the vascularized bone regeneration.
[Advanced Healthcare Materials] |
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| Investigators used peptides derived from proteins mediating cell-ECM (e.g. RGD and IKVAV) and cell-cell (e.g. HAVDI) adhesions to mediate endothelial cell attachment and coverage.
[Biofabrication] |
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| Using RNA sequencing, cytokine arrays, and single-cell RNA sequencing, scientists revealed an enrichment of cancer-associated fibroblast-derived collagen type 1 and tumor-cell-derived CXCL1 in non-responsive patient-derived xenografts.
[Cell Reports] |
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| Researchers described a new role for the autophagy-inducing serine/threonine kinases ULK1 and ULK2 in mechanotransduction, and showed that ULK1/2 activity inhibited the assembly of actin stress fibers and focal adhesions.
[EMBO Reports] |
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| To understand the role of physicochemical surface effects on the dedifferentiation of patient-derived mature adipocytes, the surfaces of cell culture flasks were coated with extracellular matrix, basement membrane proteins, and cationic/anionic polymers.
[Biomaterials Science] |
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| Researchers showed that macrophage filopodia produced a unique membrane structure called “filopodial tip vesicle” (FTV) that originated from the tip of macrophages filopodia, contained numerous internal-vesicles, and functioned as cargo storage depots via nanotubular transport.
[Cell Communication And Signaling] |
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| The authors review the relationship between ferroelectric, piezoelectric, and pyroelectric effects and the fundamental principles of different catalytic reactions.
[Advanced Materials] |
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| Scientists review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes, and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases.
[Cell Death Discovery] |
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| If Illumina does not complete its task in the next 12 to 15 months, the commission noted it could “impose periodic penalty payments” of up to 5% of the companies’ daily income.
[Fierce Biotech] |
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| November 16 – 18, 2023
Boston, Massachusetts, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | EPFL – Lausanne, Switzerland |
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| | Washington University in St. Louis – Saint Louis, Missouri, United States |
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| | The Leibniz Institute of Polymer Research Dresden – Dresden, Germany |
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| | Institut de Biologie Paris Seine – Paris, France |
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