Extracellular Matrix News Volume 14.45 | Nov 09 2023

November 9, 2023

2023-11-09 | ECM 14.45

Extracellular Matrix News by STEMCELL Technologies

Vol. 14.45 – 9 November, 2023

TOP STORY

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Vitamin B6 supplementation in combination with one-carbon metabolism blockage effectively diminished tumor burden in vivo.
[Cancer Discovery]

Abstract

An ISSCR 2021 Innovation Showcase Webinar: Facilitating hPSC Workflows with CloneR ™2, presented by Dr. Adam Hirst. Click to Watch Now.

PUBLICATIONSRanked by the impact factor of the journal

Hydrophobic Cross-Linked Chains Regulate High Wet Tissue Adhesion Hydrogel with Toughness, Anti-Hydration for Dynamic Tissue Repair

Investigators constructed anti-hydration gelatin-acrylic acid-ethylene dimethacrylate hydrogels with hydrophobic cross-linked chains.
[Advanced Materials]

Abstract

In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials

A new bio-active fish skin scaffold was shown using in situ cross-linked scaleless freshwater fish skin adding adipose-derived stem cells-produced exosomes for hemostasis and wound healing.
[Small]

Abstract

Mmp14 Is Required for Matrisome Homeostasis and Circadian Rhythm in Fibroblasts

Researchers showed that the collagenase membrane type I-matrix metalloproteinase, encoded by Mmp14, was regulated by the circadian clock in postnatal mouse tendon.
[Matrix Biology]

Abstract

Fibroblast Activation Protein Drives Tumor Metastasis via a Protease-Independent Role in Invadopodia Stabilization

Mechanistically, fibroblast activation protein was localized at invadopodia and required for invadopodia-mediated ECM degradation independent of its proteolytic activity.
[Cell Reports]

Full Article Graphical Abstract

Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique

Scientists described the production of shape-designable cartilage using a novel cell self-aggregation technique and chondroprogenitor cells derived from human induced pluripotent stem cells as the source.
[Biomedical Materials]

Abstract

Using Decellularized Magnetic Microrobots to Deliver Functional Cells for Cartilage Regeneration

Researchers introduced a novel cell microcarrier, magnetized cartilage ECM-derived scaffolds, which were derived from decellularized natural porcine cartilage ECM.
[Small]

Abstract

Essentiality of Nfatc1 Short Isoform in Osteoclast Differentiation and Its Self-Regulation

The authors engineered nuclear factor of activated T cell 1 (Nfatc1) short form-specific knockout mice and found that these mice died in utero by day 13.5.
[Scientific Reports]

Full Article

Primary Breast Tumor Induced Extracellular Matrix Remodeling in Premetastatic Lungs

Scientists assessed ECM remodeling in vivo in premetastatic lungs of female mice growing orthotopic primary breast tumor xenografts, as compared to lungs of control mice without tumors.
[Scientific Reports]

Full Article

Your Online Resource for Cell Visualization. View StainsFile.

REVIEWS

Chemical and Biological Engineering Strategies to Make and Modify Next-Generation Hydrogel Biomaterials

The authors highlight how advances in synthetic, semisynthetic, and bio-based chemistries have played a critical role in the triggered creation and customization of next-generation hydrogel biomaterials.
[Matter]

Abstract

Alleviating Hypoxia to Improve Cancer Immunotherapy

Researchers discuss the mechanisms of tumor tissue hypoxia and its impacts on immune cells and cancer immunotherapy, as well as the approaches to induce tumor vascular normalization.
[Oncogene]

Abstract

INDUSTRY AND POLICY NEWS

NurExone
Biologic Receives FDA Orphan-Drug Designation, Accelerating Development of ExoPTEN therapy for Acute Spinal Cord Injury Treatment

The designation covers the use of MSC-derived small extracellular vesicles loaded with short and modified interfering RNA targeting the phosphatase and tensin homolog (PTEN) protein for acute spinal cord injury, as implemented in the company’s ExoPTEN drug under development.
[NurExone Biologic, Inc. (Globe Newswire)]

Press Release

FEATURED EVENT

Extracellular Matrix News Volume 14.45 | Nov 09 2023

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Hydrophobic Cross-Linked Chains Regulate High Wet Tissue Adhesion Hydrogel with Toughness, Anti-Hydration for Dynamic Tissue Repair

In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials

Mmp14 Is Required for Matrisome Homeostasis and Circadian Rhythm in Fibroblasts

Fibroblast Activation Protein Drives Tumor Metastasis via a Protease-Independent Role in Invadopodia Stabilization

Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique

Using Decellularized Magnetic Microrobots to Deliver Functional Cells for Cartilage Regeneration

Essentiality of Nfatc1 Short Isoform in Osteoclast Differentiation and Its Self-Regulation

Primary Breast Tumor Induced Extracellular Matrix Remodeling in Premetastatic Lungs

Chemical and Biological Engineering Strategies to Make and Modify Next-Generation Hydrogel Biomaterials

Alleviating Hypoxia to Improve Cancer Immunotherapy

NurExone
Biologic Receives FDA Orphan-Drug Designation, Accelerating Development of ExoPTEN therapy for Acute Spinal Cord Injury Treatment

Donor Selection & Cell Source Summit

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Research Fellow – Extracellular Matrix

Postdoctoral Associate – Cell Biology and Biochemistry

PhD Position – Skin Vascular Niche

Postdoctoral Associate – Skin and ECM Biology

Postdoctoral Researcher – Breast Cancer Program

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