Extracellular Matrix News Volume 14.47 | Nov 23 2023

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    Jamie Kang
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    2023-11-23 | ECM 14.47


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.47 – 23 November, 2023
    TOP STORY

    Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-Influenza A Vaccine

    Scientists designed and evaluated single-component self-assembling protein nanoparticles (SApNPs) presenting the conserved extracellular domain of matrix protein 2 as vaccine candidates against influenza A viruses.
    [ACS Nano]

    Full ArticleGraphical Abstract
    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Meniscus-Inspired Self-Lubricating and Friction-Responsive Hydrogels for Protecting Articular Cartilage and Improving Exercise

    Inspired by the components and functions of the meniscus, scientists developed a self-lubricating and friction-responsive hydrogel that contained nanoliposomes loaded with diclofenac sodium and Kartogenin for anti-inflammation and cartilage regeneration.
    [ACS Nano]

    Abstract

    Engineering Large and Geometrically Controlled Vascularized Nerve Tissue in Collagen Hydrogels to Restore Large-Sized Volumetric Muscle Loss

    Researchers expanded the applicability of collagen hydrogels in fabricating large vascularized nerve tissue constructs for repairing volumetric muscle loss and restoring muscle function.
    [Biomaterials]

    AbstractGraphical Abstract

    Rapid Intrafibrillar Mineralization Strategy Enhances Adhesive–Dentin Interface

    A prebonding rapid intrafibrillar mineralization strategy was developed. Endogenous matrix metalloproteinases as well as exogenous bacterial erosion were inhibited, thus reducing the degradation of dentin collagen.
    [Journal Of Dental Research]

    Abstract

    Tumor-Derived Exosomal linc00881 Induces Lung Fibroblast Activation and Promotes Osteosarcoma Lung Migration

    Investigators showed that linc00881 promoted the migration of osteosarcoma cells to the lung and induced the conversion of normal lung fibroblasts into cancer-associated fibroblasts.
    [Cancer Cell International]

    Full Article

    Alpha-Mangostin Alleviate Renal Interstitial Fibrosis via Suppression of TGF-β1/Smad/ERK Signaling Axis In Vitro and In Vivo

    Scientists determined the effect of α-mangostin (α-MG) treatment in mediating the process of renal interstitial fibrosis. They found that α-MG could alleviate tubule-interstitial damage and decrease fibrotic, and epithelial-mesenchymal transition protein expression in mice with chronic kidney disease.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    Effects of Covalent or Noncovalent Binding of Different Polyphenols to Acid-Soluble Collagen on Protein Structure, Functionality, and Digestibility

    The structure, function, and digestibility of noncovalent complexes and covalent conjugates formed by acid-soluble collagen with polyphenols of different structures were investigated.
    [Journal Of Agricultural And Food Chemistry]

    AbstractGraphical Abstract

    Integrin-Based Adhesions Promote Cell-Cell Junction and Cytoskeletal Remodeling to Drive Embryonic Wound Healing

    Researchers found that the cells adjacent to wounds in the Drosophila embryonic epidermis also polarized Talin, a core component of cell-ECM adhesions.
    [Journal Of Cell Science]

    Abstract

    Keratinized Tissue Augmentation Using Collagen-Based Soft Tissue Substitute with/without Epidermal Growth Factor on Buccally Positioned Implants: A Pilot Preclinical Study

    Scientists investigated the effect of epithelial growth factor with collagen matrix on the gain of KT for buccally positioned implants in dogs.
    [Clinical Oral Investigations]

    Abstract
    A Labroots 2021 Webinar: iPSCs As Models, Part 1: What Are Induced Pluripotent Stem Cells and How Do You Use Them?, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    REVIEWS

    Regeneration of Joint Surface Defects by Transplantation of Allogeneic Cartilage: Application of iPS Cell-Derived Cartilage and Immunogenicity

    The authors review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including induced pluripotent stem cell-derived cartilage.
    [Inflammation And Regeneration]

    Full Article
    INDUSTRY AND POLICY NEWS

    BioStem Technologies Awarded Q Code for VENDAJE AC® Line from Centers for Medicare and Medicaid Services

    VENDAJE AC is a human connective tissue matrix comprised of dehydrated amniotic/chorionic tissue processed using BioStem’s proprietary BioREtain® process.
    [BioStem Technologies, Inc.]

    Press Release
    FEATURED EVENT

    First Alpine Winter School for Biofabrication

    January 10 – 13, 2024
    Radstadt, Austria

    > See All Events

    JOB OPPORTUNITIES

    PhD Studentship – Role of Extracellular Matrix in Hypoxic Metastasis

    University of Nottingham – Nottingham, England, United Kingdom

    Research Fellow – Immune cells, Stromal cells and the Extracellular Matrix in Asthma

    University of Aberdeen – Aberdeen, Scotland, Untied Kingdom

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Fellow – Extracellular Matrix

    National University of Singapore – Singapore, Singapore

    Postdoctoral Associate – Cell Biology and Biochemistry

    Stony Brook University – Stony Brook, New York, United States
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