Extracellular Matrix News Volume 14.48 | Nov 30 2023

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    Jamie Kang
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    2023-11-30 | ECM 14.48


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.48 – 30 November, 2023
    TOP STORY

    Genetically Encoding Multiple Functionalities into Extracellular Vesicles for the Targeted Delivery of Biologics to T Cells

    Researchers reported a suite of methods for the genetic engineering of cells to produce extracellular vesicles for the targeted delivery of biologics to T cells without the need for chemical modifications.
    [Nature Biomedical Engineering]

    AbstractPress Release
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    Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain

    Scientists investigated the impact of nanoparticle surface chemistry using layer-by-layer assembly to design drug carriers for broad spatial distribution in brain tissue and specific glioblastoma cell targeting. They found that poly-l-glutamate and hyaluronate were effective surface chemistries for targeting glioblastoma cells.
    [ACS Nano]

    AbstractGraphical Abstract

    hsdSA Regulated Extracellular Vesicle-Associated PLY to Protect Streptococcus pneumoniae from Macrophage Killing via LAPosomes

    hsdSA regulated the production of extracellular vesicles which package cytosolic, surface, and secreted proteins, including pneumolysin (PLY).
    [Microbiology Spectrum]

    Full Article

    Mouse Gingival Single-Cell Transcriptomic Atlas Identified a Novel Fibroblast Subpopulation Activated to Guide Oral Barrier Immunity in Periodontitis

    Scientists reported a unique fibroblast subpopulation activated to guide oral inflammation identified in a single-cell RNA sequencing gingival cell atlas constructed from the mouse periodontitis models.
    [eLife]

    Full Article

    A Proteomic Meta-Analysis Refinement of Plasma Extracellular Vesicles

    Investigators performed a proteomics meta-analysis of public data to refine the plasma extracellular vesicles (EV) composition by separating EV proteins and contaminants into different clusters.
    [Scientific Data]

    Full Article

    The Antioxidant Glycitin Protects Against Intervertebral Disc Degeneration through Antagonizing Inflammation and Oxidative Stress in Nucleus Pulposus Cells

    Researchers found that Glycitin alleviated TNF-α-induced metabolic disorders, ECM degradation, oxidative stress, inflammation responses, and mitochondrial damage.
    [Aging]

    Full Article

    Phosphoproteomic Changes Induced by Cell-Derived Matrix and their Effect on Tumor Cell Migration and Cytoskeleton Remodeling

    Investigators combined a cell-derived matrix model with phosphotyrosine phosphoproteomic analysis to investigate tumor cell migration on fibrotic ECM relative to standard tissue culture plastic.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    The Treatment with Trandolapril and Losartan Attenuates Pressure and Volume Overload Alternations of Cardiac Connexin-43 and Extracellular Matrix in Ren-2 Transgenic Rats

    Researchers explored a dual impact of pressure, and volume overload due to aortocaval fistula on connexin-43 and ECM as well as the effect of renin–angiotensin blockade.
    [Scientific Reports]

    Full Article

    Assessing Type I Collagen Expression and Quality in Cellular Models of Osteogenesis Imperfecta

    Scientists reported an immunofluorescence assay for the detection of type I collagen in fibroblast models of osteogenesis imperfecta and represented them into two broad categories based on the expression level and aggregation characteristics of pro-α1.
    [Clinical Genetics]

    Abstract
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    REVIEWS

    The Collagen Matrix Regulates the Survival and Function of Pancreatic Islets

    The authors provide insights into the treatment of type 1 diabetes mellitus to prolong life expectancy and provide the potential targets for treating collagen deposition-induced pancreatic fibrosis and pancreatic carcinoma.
    [Endocrine]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Anika Announces First Surgeries Performed using the Integrityâ„¢ Implant System, a Regenerative Hyaluronic Acid-Based Patch System for Rotator Cuff Repairs, Commencing Limited Market Release

    Anika Therapeutics, Inc. announced that the first surgeries using the Integrity Implant System. Integrity was designed to protect an injured tendon and promote healing in rotator cuff repair and other tendon procedures using a hyaluronic acid-based scaffold with bone and tendon fixation components.
    [Anika Therapeutics, Inc.]

    Press Release
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    JOB OPPORTUNITIES

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    ETH Zurich – Zurich, Switzerland

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    Camperdown, Australia – University of Sydney

    PhD Studentship – Role of Extracellular Matrix in Hypoxic Metastasis

    University of Nottingham – Nottingham, Scotland, United Kingdom

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Fellow – Extracellular Matrix

    National University of Singapore – Singapore, Singapore

    > See All Jobs

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