 | | Vol. 14.50 – 14 December, 2023 |
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| By combining NMR, biochemistry, and cell biology techniques, scientists found that talin and kindlin binding to the β-tail could induced a conformational change that increased talin affinity and decreased kindlin affinity toward it.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers modeled the early interactions between epicardial cells and cardiomyocytes to generate a population of fibroblasts that recapitulated many aspects of fibroblast behavior in vivo, including changes associated with maturation and in response to pathological stimuli associated with cardiac injury.
[Nature Communications] |
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| A tumor-targeting and tumor microenvironment-responsive “smart” lipid nanoparticle was presented, which was capable of delivering and releasing H2S specifically in tumor tissues for on-demand H2S gas and photodynamic immunotherapy.
[Journal Of The American Chemical Society] |
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| Compared to traditional hydrogels, microgel-fiber hydrogel possessed a highly interconnected network with micron-sized pores, demonstrating favorable properties for cell adhesion and penetration in in vitro experiments.
[Small] |
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| Researchers acquired scRNA-seq datasets about HCC, which enabled them to identify distinct cell subpopulations within HCC tissues. They conducted a differential analysis to pinpoint DEGs associated with normal fibroblasts and cancer-associated fibroblasts.
[NPJ Precision Oncology] |
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| Scientists investigated the function of macrophage GPER1 in the unilateral ureteral obstruction (UUO)-induced renal fibrosis model. Fibroblasts co-cultured with G-1-pretreated M2 macrophages showed downregulated extracellular matrix expression.
[Cell Death & Disease] |
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| Researchers developed a magnetic microrobot by using natural materials derived from the ECM to mimic the ligand–receptor interaction between cancer cells and the ECM, offering targeted elimination of cancer cells.
[Nanoscale] |
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| Investigators prepared a viscoelastic hydrogel matrix with a storage modulus of about 2 kPa and a loss modulus adjustable from 0 to 600 Pa, through adding linear alginate and regulating the compactness of a polyacrylamide covalent network.
[Journal Of Materials Chemistry B] |
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| Researchers examined whether the inhibition of bundling of collagen fibrils using a potent lysyl oxidase inhibitor, β-aminopropionitrile changed the cellular network of the chick calvaria.
[Scientific Reports] |
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| The authors provide a landscape of the latest progress on the convergence of 3D bioprinting and tumor organoids. Furthermore, they discuss the potential to incorporate organ-on-a-chip with bioprinting tumor organoids to improve the biomimicry and predictability of therapeutic performance.
[Trends In Biotechnology] |
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| 89bio, Inc. announced a successful end-of-phase II Meeting with the US FDA, supporting the advancement of pegozafermin into Phase III in NASH. The program will include two Phase III trials evaluating patients with NASH: ENLIGHTEN-Cirrhosis and ENLIGHTEN-Fibrosis.
[nan] |
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| January 27 – 30, 2024
Pacific Grove, California, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Utrecht University – Utrecht, Netherlands |
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| | University of Montpellier – Montpellier, France |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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