Extracellular Matrix News Volume 15.02 | Jan 18 2023

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    2024-01-18 | ECM 15.03


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.02 – 18 January, 2024
    TOP STORY

    Deciphering Tumor Microenvironment: CXCL9 and SPP1 As Crucial Determinants of Tumor-Associated Macrophage Polarity and Prognostic Indicators

    The collaborative actions of CXCL9 and SPP1 were found to collectively dictate the polarity of tumor-associated macrophages within the tumor microenvironment, exerting profound effects on tumor progression and treatment responses.
    [Molecular Cancer]

    Full Article
    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity

    Researchers designed a protease-activated fibronectin (FN1) and/or tenascin C (TNC) binding peptide (FTF) and proposed an ECM-trapped bioinspired lipoprotein that could be preferentially captured by the TNC and/or FN1 for tumor retention.
    [Advanced Materials]

    Abstract

    Cell Membrane-Anchored and Tumor-Targeted IL-12 T-Cell Therapy Destroys Cancer-Associated Fibroblasts and Disrupts Extracellular Matrix in Heterogenous Osteosarcoma Xenograft Models

    Investigators used RNA sequencing to assess whether the recently invented membrane-anchored and tumor-targeted IL-12-armed T cells, which boundd cell-surface vimentin on tumor cells, could destroy cancer-associated fibroblasts to disrupt the extracellular matrix.
    [Journal For Immunotherapy Of Cancer]

    Full Article

    Modified Carbon Nanotubes Favor Fibroblast Growth by Tuning the Cell Membrane Potential

    Scientists explored the hypothesis that electrostatic fields generated at the interface between nonexcitable cells and appropriate scaffold might favor cell growth by tuning their membrane potential. They focused on primary human fibroblasts grown on electrospun polymer fibers with embedded multiwall carbon nanotubes.
    [ACS Applied Materials & Interfaces]

    Full ArticleGraphical Abstract

    The Extracellular Matrix Supports Breast Cancer Cell Growth under Amino Acid Starvation by Promoting Tyrosine Catabolism

    The authors demonstrated that the presence of ECM supported the growth of invasive breast cancer cells, but not non-transformed mammary epithelial cells, under amino acid starvation, through a mechanism that required macropinocytosis-dependent ECM uptake.
    [PLOS Biology]

    Full Article

    Recent Advances in Production of Sustainable and Biodegradable Polymers from Agro-Food Waste: Applications in Tissue Engineering and Regenerative Medicines

    Investigators highlight recent advances in the development of biopolymers from agro-food waste and their potential for future tissue engineering and regenerative medicine applications, including drug delivery, wound healing, tissue engineering, and more.
    [International Journal Of Biological Macromolecules]

    Abstract

    Vaginal Reconstruction by Collagen Scaffolds Loaded with Vaginal Epithelial and Smooth Muscle Cells in Pigs

    Researchers established a new method for isolation and expansion of vaginal epithelial and smooth muscle cells. Subsequently, collagen scaffolds designed for vaginal reconstruction were loaded with vaginal epithelial and smooth muscle cells in vitro and tested in vivo using the vaginal excision pig model.
    [Biomaterials Science]

    Abstract

    Priming Chondrocytes during Expansion Alters Cell Behavior and Improves Matrix Production in 3D Culture

    Chondrocytes were isolated from juvenile bovine knee joints and cultured with or without a growth factor cocktail. Gene expression, cell morphology, cell adhesion, cytoskeletal protein distribution, and cell mechanics were assessed.
    [Osteoarthritis And Cartilage]

    Full Article

    Single-Cell Sequencing Reveals Increased LAMB3-Positive Basal Keratinocytes and ZNF90-Positive Fibroblasts in Autologous Cultured Epithelium

    Functional analyses showcased active cellular metabolism in LAMB3+ basal keratinocytes, vital in ECM homeostasis, while ZNF90+ fibroblasts demonstrated increased differentiation, essential in collagen formation for cell adhesion.
    [Communications Biology]

    Full Article
    Learn how to stay motivated in research.
    REVIEWS

    Extracellular Matrix Dynamics: A Key Regulator of Cell Migration Across Length-Scales and Systems

    Scientists discuss recent studies that have shone light on how ECM deposition and organization and the resulting mechanical and chemical signals contribute to modulating cell migration.
    [Current Opinion In Cell Biology]

    Abstract

    Permissive Role of Vascular Endothelium in Fibrosis

    The deepening knowledge of the chain of pathogenetic events involving endothelial cells, namely increased permeability, stiffening of the matrix, endothelial dysfunction, microvascular rarefaction, and tissue fibrosis, may provide a roadmap for therapeutic interventions deemed to curtail and reverse fibrosis.
    [American Journal Of Physiology-Cell Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Postdoctoral Researchers Awarded Hartwell Fellowships to Probe Tissue Regeneration and Molecular Roots of Dystonia

    Ben Cox and Rebecca McGillivary, postdoctoral researchers in the Department of Molecular and Cellular Biology, are among 10 early career scientists selected to receive 2022 Hartwell Biomedical Research Fellowships, which were announced in August, 2023.
    [UC Davis]

    Press Release
    FEATURED EVENT

    2024 ACS Cancer Conference

    February 22 – 24, 2024
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Flatworm Bioadhesion

    University of Innsbruck – Innsbruck, Austria

    Postdoctoral Position – Tumor Microenvironment

    University of Lund – Lund, Sweden

    Assistant Professor – Stem Cell Biology in Rare Diseases

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Researchers – Advanced Imaging & 3D Genome Analysis in Cancer Biology

    Karolinska Institutet – Solna, Sweden

    Postdoctoral Fellow – Regenerative Medicine

    University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States

    > See All Jobs

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