Extracellular Matrix News Volume 15.06 | Feb 15 2024

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    2024-02-15 | ECM 15.06


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.06 – 15 February, 2024
    TOP STORY

    In Vivo Stimulation of Therapeutic Antigen-Specific T Cells in an Artificial Lymph Node Matrix

    Researchers created an artificial lymph node matrix, which consisted of an extracellular matrix hydrogel conjugated with peptide-loaded-MHC complex, the co-stimulatory signal anti-CD28, and a tethered IL-2, that could bypass challenges faced by other approaches to activate T cells in situ.
    [Advanced Materials]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Rice Grains Integrated with Animal Cells: A Shortcut to a Sustainable Food System

    The potential of rice grains as cell scaffolds is demonstrated by investigating the interactions between the coating, grains, and cells.
    [Matter]

    Full ArticlePress Release

    Elastic Porous Microspheres/Extracellular Matrix Hydrogel Injectable Composites Releasing Dual Bio-Factors Enable Tissue Regeneration

    Investigators developed a biomaterial system consisting of elastic porous poly(l-lactide-co-ε-caprolactone) microspheres mixed with ECM hydrogels as injectable composites with interleukin-4 and insulin-like growth factor-1 dual-release functionality.
    [Nature Communications]

    Full Article

    An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis after Angioplasty

    A stent-free anti-stenosis drug coating based on a peptide hydrogel was proposed. The hydrogel was formed by assembling a nitric oxide donor-peptide conjugate as a hydrogelator and encapsulating curcumin during the assembly process.
    [Advanced Science]

    Full Article

    Brain-Decellularized ECM-Based 3D Myeloid Sarcoma Platform: Mimicking Adaptive Phenotypic Alterations in the Brain

    Researchers presented a novel 3D in vitro model mimicking intracranial myeloid sarcoma, employing a hydrogel scaffold derived from the brain-decellularized ECM in which suspended leukemia cells were embedded, simulating the formation of tumor masses in the brain parenchyma.
    [Advanced Healthcare Materials]

    Abstract

    An Animal Study on the Effectiveness of Platelet-Rich Plasma as a Direct Pulp Capping Agent

    Scientists investigated the effectiveness of Platelet Rich Plasma vs. Mineral Trioxide Aggregate as a direct pulp capping agent. 42 teeth from three mongrel dogs were divided into two equal groups.
    [Scientific Reports]

    Full Article

    Collagenase-Based Wound Debridement Agent Induces Extracellular Matrix Supporting Phenotype in Macrophages

    Scientists explored the phenotypes and subsets of macrophages following treatment with the active constituent of Collagenase Santyl® Ointment.
    [Scientific Reports]

    Full Article

    Collagen Networks under Indentation and Compression Behave Like Cellular Solids

    Scientists investigated the mechanical response of collagen-1 networks to local and bulk compressive loads. They compared these results to the behavior of polyacrylamide, a fundamentally different class of hydrogel network consisting of flexible polymer chains.
    [Langmuir]

    AbstractGraphical Abstract

    Modification of the Inflammatory Profile of Mesenchymal Stem Cells Using Different Culture Conditions

    Mesenchymal stem cells (MSCs) were cultured by three strategies: seeding on an extracellular matrix (ECM), spheroids in static culture, and spheroids in a bioreactor.
    [Regenerative Medicine]

    AbstractGraphical Abstract
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    REVIEWS

    Enhancing Osteoporosis Treatment with Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles: Mechanisms and Advances

    The authors review advancements in utilizing MSCs and their derived extracellular vesicles (EV) for osteoporosis (OP) treatment. It systematically examines the most extensively researched MSC-derived EVs for treating OP.
    [Cell Death & Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    A New Approach to Producing Artificial Cartilage with the Help of 3D Printing

    A special high-resolution 3D printing process is used to create tiny, porous spheres made of biocompatible and degradable plastic, which are then colonized with cells.
    [phys.org]

    Press Release
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