Extracellular Matrix News Volume 15.08 | Feb 29 2024

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    2024-02-29 | ECM 15.08


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.08 – 29 February, 2024
    TOP STORY

    PolyGR and polyPR Knock-In Mice Reveal a Conserved Neuroprotective Extracellular Matrix Signature in C9orf72 ALS/FTD Neurons

    Investigators generated C9orf72 dipeptide repeat knock-in mouse models characterized by the expression of 400 codon-optimized polyGR or polyPR repeats and heterozygous C9orf72 reduction.
    [Nature Neuroscience]

    Full Article
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    Oleic Acid-PPARγ-FABP4 Loop Fuels Cholangiocarcinoma Colonization in Lymph Node Metastases Microenvironment

    Scientists determined whether metabolic reprogramming fueled the adaptation and remodeling of cholangiocarcinoma cells to the lymph node microenvironment.
    [Hepatology]

    AbstractGraphical Abstract

    Boosting Cartilage Repair with Silk Fibroin-DNA Hydrogel-Based Cartilage Organoid Precursor

    Researchers developed a novel RGD-SF-DNA hydrogel microsphere via a microfluidic system by integrating photopolymerization with self-assembly techniques and then modified with Pep-RGDfKA. In vitro studies demonstrated that RSD-MSs enhanced BMSCs proliferation and chondrogenic differentiation.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Devastating the Supply Wagons: Multifaceted Liposomes Capable of Exhausting Tumor to Death via Triple Energy Depletion

    A novel treatment of starving-like therapy—triple energy-depleting therapy—is illustrated by glucose oxidase/dc-IR825/sorafenib liposomes, and such a triple energy-depleting therapy exhibits a more effective tumor-killing effect than conventional starvation therapy that only cuts off one of the energy supplies.
    [Small]

    Abstract

    FGF18 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting the NF-κB Pathway

    A mouse model of acute lung injury and HUVECs stimulated with lipopolysaccharides was established in vivo and in vitro. AAV-FGF18 and fibroblast growth factor 18 (FGF18) proteins were used in C57BL/6J mice and HUVEC, respectively.
    [Respiratory Research]

    Full Article

    Core-Shell Nanofibers Containing L-Arginine Stimulates Angiogenesis and Full Thickness Dermal Wound Repair

    Coaxial electrospinning was employed to fabricate core–shell nanofiber-based wound dressing, with a core composed of polyacrylamide and a shell comprising 0.5 % solution of L-Arginine in aloe vera and keratin.
    [International Journal Of Pharmaceutics]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Mineralized Collagen Scaffolds for Regenerative Engineering Applications

    Scientists summarize key considerations regarding the current state-of-the-art design and use of collagen biomaterials for tissue engineering applications.
    [Current Opinion In Biotechnology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Early Pulmonary Fibrosis Detection Holds the Key to Better Health Outcomes for Canadians Living with COVID-19 and Rheumatoid Arthritis

    Canadians who have had COVID-19, and other chronic diseases, are experiencing pulmonary fibrosis at significantly higher rates than others, seemingly providing a causal link that researchers are investigating.
    [The Whig]

    Press Release
    FEATURED EVENT

    2024 Fibroblast Growth Factors in Development and Disease Conference GRC

    March 24 – 29, 2024
    Galveston, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Cancer Cells and Extracellular Matrix

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoc Research Associate – Biomaterial-Cell Interactions

    University of Sydney – Sydney, Australia

    Research Associate – Breast Cancer and Brain Tumors

    Cedars Sinai Medical Center – Los Angeles, California, United States

    Researcher – Characterization and Engineering of Biogenic Extracellular Vesicles

    Center for Colloid and Surface Science – Florence, Italy

    Postdoctoral Scientist – Liver Cancer Immunology

    Foundation for Liver Research – London, England, United Kingdom

    > See All Jobs

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