 | | Vol. 15.11 – 28 March, 2024 |
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| Researchers identified three major morphological and functional variants that co-existed in varying proportions in all pancreatic ductal carcinoma, displayed limited genetic diversity, and were associated with a distinct organization of the ECM.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In newly generated, clinically-relevant somatic female hepatocellular carcinoma (HCC) mouse models, investigators identified cancer genetics’ specific and stage-dependent alterations of the liver tumor microenvironment associated with distinct histopathological and malignant HCC features.
[Nature Communications] |
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| Scientists designed a dual functional biologic-released bioadhesive comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrated chemo-mechanical restoration with inner meniscal regeneration.
[Nature Communications] |
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| Using a small animal “bioreactor”, investigators bioengineered full-scale ears utilizing decellularized cartilage xenograft placed within a 3D-printed external auricular scaffold that mimics the size, shape, and biomechanical properties of the native human auricle.
[Acta Biomaterialia] |
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| A bilayer scaffold with a top layer comprising 3D printed pectin/polyacrylic acid/platelet rich fibrin hydrogel and a bottom nanofibrous layer containing Pec/PAA/simvastatin was produced.
[International Journal Of Biological Macromolecules] |
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| Researchers investigated the changes in Young’s modulus, storage modulus, loss modulus, and porosity of native and decellularized bovine reproductive tissues during the estrous cycle.
[Scientific Reports] |
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| Multiple bioinformatics techniques have been employed to investigate the roles of procollagen c-protease enhancer protein (PCOLCE) in glioma, consisting of the correlation between PCOLCE and prognosis, immune checkpoints, immune cell infiltrates, and tumor microenvironment.
[Heliyon] |
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| Scientists observe that the role of the innate immune pathway demonstrates heterogeneity, links to the tumor development stage, pathway status, and specific cell types. They propose that within the tumor microenvironment, the innate immune pathway exhibits multidimensional diversity.
[Signal Transduction And Targeted Therapy] |
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| Metal–organic frameworks (MOF)-based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration.
[Small] |
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| Patients could get a single shot in the joint that would not only stop their cartilage and bone from eroding, but kick start its regrowth. The Advanced Research Projects Agency for Health awarded up to $39 million to a University of Colorado Boulder-led team of scientists to work toward making this dream a reality.
[University of Colorado] |
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| May 6 – 8, 2024
Prague, Czech Republic |
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| | University of Colorado – Aurora, Colorado, United States |
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| | Sapienza University – Rome, Italy |
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| | Umeå University – Umeå, Sweden |
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| | abbvie – Irvine, California, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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Cancer Stem Cell News
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